CMV INFECTIONS IN AIDS PATIENTS ON ANTI-VIRAL CLINICAL PROTOCOLS

接受抗病毒临床治疗的艾滋病患者的巨细胞病毒感染

• 批准号: 6293724
• 负责人: J. F MANISCHEWITZ
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6293724
• 关键词: AIDS; AIDS therapy; CD4 molecule; adenine analog; clinical research; clinical trial phase I; cytomegalovirus; cytosine analog; diagnosis quality /standard; diagnostic respiratory lavage; human subject; interferon alpha; interleukin 2; microorganism disease chemotherapy; opportunistic infections; virus classification; zidovudine

(1) Goals of Project: - Since CMV is recognized as one of the leading opportunistic infections in AIDS patients, it is important to monitor blood, urine, and tissue specimens from patients enrolled in various clinical trials for the presence of CMV. - Determine whether elevated CD4 counts resulting from triple therapy against HIV are effective in controling CMV retinitis. (2) Purpose of Clinical Protocols: To determine whether immune function in HIV-infected individuals with elevated CD4+ counts on potent antiviral therapy is effective in controlling CMV retinitis without specific anti- CMV therapy. (3) Results to date: No patient has had reactivation of CMV retinitis or has developed extraocular CMV disease after 1 year following discontinuation of anti-CMV therapy.

(1)项目目标：-由于巨细胞病毒被认为是艾滋病患者中主要的机会性感染之一，因此对参加各种临床试验的患者的血液、尿液和组织标本进行巨细胞病毒检测非常重要。-确定三联治疗引起的CD4计数升高是否对控制巨细胞病毒性视网膜炎有效。(2)临床方案目的：探讨在不进行特异性抗巨细胞病毒治疗的情况下，CD4+计数升高的hiv感染者免疫功能是否能有效控制巨细胞病毒视网膜炎。(3)迄今为止的研究结果：在停止抗巨细胞病毒治疗1年后，没有患者再次发生巨细胞病毒视网膜炎或发生眼外巨细胞病毒疾病。