CMV infections in AIDS patients on clinical protocols

临床方案中艾滋病患者巨细胞病毒感染

• 批准号: 6545128
• 负责人: J. F MANISCHEWITZ
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6545128
• 关键词: AIDS; AIDS therapy; CD4 molecule; blood tests; cell population study; clinical trials; comorbidity; cytomegalovirus; human subject; human therapy evaluation; immunoregulation; longitudinal human study; microorganism disease chemotherapy; opportunistic infections; patient oriented research; retinitis; urinalysis; virus diseases

Summary: (1) Goals of Project: - Since CMV is recognized as one of the leading opportunistic infections in AIDS patients, it is important to monitor blood, urine, and tissue specimens from patients enrolled in various clinical trials for the presence of CMV. - Determine whether elevated CD4 counts resulting from triple therapy against HIV are effective in controling CMV retinitis. (2) Purpose of Clinical Protocols: To determine whether immune function in HIV-infected individuals with elevated CD4+ counts on potent antiviral therapy is effective in controlling CMV retinitis without specific anti- CMV therapy. (3) Results to date: No patient has had reactivation of CMV retinitis or has developed extraocular CMV disease after 1 year following discontinuation of anti-CMV therapy. Publication in preparation: Successful discontinuation of specific anti-cytomegalovirus therapy in persons with HIV infection and cytomegalovirus retinitis: Results of a longitudinal intervention trial.

摘要：（1）项目目标： - 由于 CMV 被认为是艾滋病患者中主要的机会性感染之一，因此监测参加各种临床试验的患者的血液、尿液和组织标本中是否存在 CMV 非常重要。 - 确定 HIV 三联疗法导致的 CD4 计数升高是否能有效控制 CMV 视网膜炎。 (2) 临床方案的目的： 目的是确定 CD4+ 计数升高的 HIV 感染者的免疫功能是否可以有效抗病毒治疗，无需特异性抗 CMV 治疗即可有效控制 CMV 视网膜炎。 (3) 迄今为止的结果： 停止抗 CMV 治疗 1 年后，没有患者出现 CMV 视网膜炎再激活或出现眼外 CMV 疾病。 准备中的出版物：在艾滋病毒感染和巨细胞病毒性视网膜炎患者中成功停止特定的抗巨细胞病毒治疗：纵向干预试验的结果。