CMV infections in AIDS patients on clinical protocols

摘要：(1)项目目标： -由于CMV被认为是艾滋病患者的主要机会性感染之一，因此监测参加各种临床试验的患者的血液、尿液和组织标本是否存在CMV是很重要的。 -确定抗艾滋病毒三联疗法导致的CD4计数升高是否对控制CMV视网膜炎有效。 (2)临床方案的目的： 为了确定CD4+细胞计数升高的HIV感染者的免疫功能，在没有特定抗CMV治疗的情况下，使用有效的抗病毒治疗是否有效控制CMV视网膜炎。 (3)迄今的结果： 在停止抗巨细胞病毒治疗一年后，无患者发生巨细胞病毒视网膜炎复发或发生眼外巨细胞病毒病。 正在筹备中的出版物：HIV感染者和巨细胞病毒视网膜炎患者中特定抗巨细胞病毒治疗的成功中断：一项纵向干预试验的结果。

Summary: (1) Goals of Project: - Since CMV is recognized as one of the leading opportunistic infections in AIDS patients, it is important to monitor blood, urine, and tissue specimens from patients enrolled in various clinical trials for the presence of CMV. - Determine whether elevated CD4 counts resulting from triple therapy against HIV are effective in controling CMV retinitis. (2) Purpose of Clinical Protocols: To determine whether immune function in HIV-infected individuals with elevated CD4+ counts on potent antiviral therapy is effective in controlling CMV retinitis without specific anti- CMV therapy. (3) Results to date: No patient has had reactivation of CMV retinitis or has developed extraocular CMV disease after 1 year following discontinuation of anti-CMV therapy. Publication in preparation: Successful discontinuation of specific anti-cytomegalovirus therapy in persons with HIV infection and cytomegalovirus retinitis: Results of a longitudinal intervention trial.