CORE--SAMPLE/TISSUE ACQUISITION

样本采集核心将提供一个集中高效的机制 提供研究方案所需的临床材料 本计划中包括的每一个人的研究项目。这个 共同关注类风湿性关节炎的免疫机制 每个单独的项目都很适合共同努力 识别和招募潜在受试者，处理血液、滑液 从受试者身上获取的液体和滑膜样本，以及 根据需要将它们分配给每个调查人员。该署署长 核心在与每个国家的首席调查员协商后 组成项目将确立选择患者的标准 患有风湿性关节炎的人进入这项研究，并将教育 护士临床协调员通过以下方式确定合适的候选人 对病历进行筛选。护士临床协调员将 参加风湿科门诊活动 筛选医疗记录以识别符合入院标准的患者 并在潜在研究的计算机化数据库中注册 候选人。由于研究需要病人，他们的医生将是 联系以获得批准和护士临床协调员或核心 然后，主任将尝试招募患者进行研究。这个 护士临床协调员将抽取所需的血样表格 那些同意参与的患者和患者的医生或 核心主任将为那些捐献的患者进行关节置换 滑液。护士临床协调员将处理血液和 滑液样本，联系个别调查人员，和 安排将样品送到研究实验室。为 这些项目需要类风湿疾病活动之间的相关性 和研究实验室的发现，将进行定量联合检查 由护士临床协调员和/或核心主任执行。

The Sample Acquisition Core will provide a centralized efficient mechanism for providing the clinical materials needed for the research protocols of each of the individuals research projects included in this program. The common focus on immunologic mechanisms in rheumatoid arthritis shared by each of the individual projects lends itself well to a unified effort to identify and recruit potential subjects, to handle the blood, synovial fluid, and synovial membrane samples obtained from the subjects, and to apportion them as needed to each of the investigators. The director of the core in consultation with the principal investigators of each of the component projects will establish the criteria for selection of patients with rheumatoid arthritis for entry into this study and will educate the Nurse Clinical Coordinator in identifying appropriate candidates by screening of the medical record. The Nurse Clinical Coordinator will attend the outpatient activities of the Division of Rheumatology and screen medical records to identify those patients meeting entry criteria and register them in a computerized database of potential research candidates. As patients are needed for research, their physician will be contacted for approval and the Nurse Clinical Coordinator or the Core Director will then attempt to recruit the patient for the studies. The Nurse Clinical Coordinator will draw the required blood specimens form those patients who agree to participate and the patient's physician or the Core Director will perform arthrocenteses for those patients donating synovial fluid. The Nurse Clinical Coordinator will process the blood and synovial fluid specimens, contact the individual investigators, and arrange for delivery of the samples to the research laboratories. For those projects requiring correlation between rheumatoid disease activity and research laboratory findings, quantitative joint examinations will be performed by the Nurse Clinical Coordinator and/or the Core Director.