CORE--SAMPLE/TISSUE ACQUISITION

核心——样本/组织采集

• 批准号: 6235772
• 负责人: HARRY G BLUESTEIN
• 金额: $ 16.46万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-05-01 至 1998-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6235772
• 关键词: biomedical facility; clinical chemistry; human subject; rheumatoid arthritis; synovial fluid; synovial membrane; tissue /cell culture

The Sample Acquisition Core will provide a centralized efficient mechanism for providing the clinical materials needed for the research protocols of each of the individuals research projects included in this program. The common focus on immunologic mechanisms in rheumatoid arthritis shared by each of the individual projects lends itself well to a unified effort to identify and recruit potential subjects, to handle the blood, synovial fluid, and synovial membrane samples obtained from the subjects, and to apportion them as needed to each of the investigators. The director of the core in consultation with the principal investigators of each of the component projects will establish the criteria for selection of patients with rheumatoid arthritis for entry into this study and will educate the Nurse Clinical Coordinator in identifying appropriate candidates by screening of the medical record. The Nurse Clinical Coordinator will attend the outpatient activities of the Division of Rheumatology and screen medical records to identify those patients meeting entry criteria and register them in a computerized database of potential research candidates. As patients are needed for research, their physician will be contacted for approval and the Nurse Clinical Coordinator or the Core Director will then attempt to recruit the patient for the studies. The Nurse Clinical Coordinator will draw the required blood specimens form those patients who agree to participate and the patient's physician or the Core Director will perform arthrocenteses for those patients donating synovial fluid. The Nurse Clinical Coordinator will process the blood and synovial fluid specimens, contact the individual investigators, and arrange for delivery of the samples to the research laboratories. For those projects requiring correlation between rheumatoid disease activity and research laboratory findings, quantitative joint examinations will be performed by the Nurse Clinical Coordinator and/or the Core Director.

样本采集核心将提供一个集中的高效机制， 提供研究方案所需的临床材料， 每个人的研究项目包括在这个计划。 的 共同关注类风湿关节炎的免疫机制， 每个单独的项目都很适合于统一的努力， 识别和招募潜在受试者，以处理血液、滑膜 从受试者获得的关节液和滑膜样品，以及 根据需要将其分配给每个调查员。 主任 核心小组与每个小组的主要调查员协商， 各组成项目将建立选择病人的标准， 参与本研究，并将教育 护士临床协调员通过以下方式确定合适的候选人： 检查医疗记录。 护士临床协调员将 参加流变学分部的门诊活动， 筛选病历，以确定符合入选标准的患者 并将其登记在一个计算机化的潜在研究数据库中 候选人 由于研究需要患者，他们的医生将 联系批准和护士临床协调员或核心 然后，主管将尝试招募患者参加研究。 的 护士临床协调员将抽取所需的血液样本表 同意参加的患者和患者的医生或 核心主任将为捐赠的患者进行关节穿刺术 滑液 护士临床协调员将处理血液， 滑液标本，联系个体研究者，以及 安排将样本运送到研究实验室。 为 那些需要类风湿性疾病活动之间相关性的项目 和研究实验室的发现，定量联合检查将 由护士临床协调员和/或核心主任执行。