SLE ANTIBODIES TO NEURONS AND LYMPHOCYTES: PATHOBIOLOGY

系统性红斑狼疮神经元和淋巴细胞抗体：病理学

• 批准号: 3152006
• 负责人: HARRY G BLUESTEIN
• 金额: $ 22.62万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1981
• 资助国家: 美国
• 起止时间: 1981-07-01 至 1987-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3152006
• 关键词: T lymphocyte; antibody formation; antigen antibody reaction; autoradiography; blood brain barrier; blood tests; cell mediated cytotoxicity; cell population study; cerebrospinal fluid; gel electrophoresis; human subject; immunoregulation; lymphocyte; membrane activity; nervous system disorder; neurons; orphan disease /drug; radiotracer; scintillation spectrometry; surface antigens; systemic lupus erythematosus; tissue /cell culture

Central nervous system dysfunction is a common occurrence in systemic lupus erythematosus, and it is one of the serious life-threatening manifestations of the disease. Immune complex-mediated vasculitis, the mechanism responsible for tissue damage in most organ systems, is rarely found in the brain of patients with CNS disease. A major research effort in this laboratory has been the investigation of the role of antibodies reactive with neuronal cells from human brain in the pathogenesis of lupus neuropsychiatric manifestations. Our studies have demonstrated that most lupus patients have circulating antibodies reactive with human neurons, and many of those antibodies are cross-reactive with antigens on human lymphocytes. A pathogenetic role for those antibodies is suggested by the close association of antineuronal antibody within the central nervous system and active CNS lupus. In this application we are proposing more detailed analysis of the disease-producing potential of the neuron and lymphocyte reactive antibodies. Our aims are to understand how these antibodies get into the nervous system and to define the antigens with which they react. We will determine if the antibodies are produced locally within the central nervous system or if they enter from the serum through a leak in the blood-brain barrier. We will investigate their reactivity with the neurotransmitter receptors that regulate brain function, and we will utilize the neuron and lymphocyte reactive antibodies to physically characterize the antigens shared by those two cell types and analyze their distribution on lymphocyte subpopulations as a probe into the potential link between altered immune regulation and nervous system dysfunction that characterize SLE.

中枢神经系统功能障碍是系统性狼疮的常见病

项目成果

Neuropsychologic deficits and antineuronal antibodies in pediatric systemic lupus erythematosus.

儿童系统性红斑狼疮的神经心理缺陷和抗神经元抗体。

• 发表时间: 1990
• 期刊: Clinical and experimental rheumatology
• 影响因子: 3.7
• 作者: Papero,PH;Bluestein,HG;White,P;Lipnick,RN
• 通讯作者: Lipnick,RN

Very late activation antigens (VLA) are human leukocyte-neuronal crossreactive cell surface antigens.

• DOI: 10.1084/jem.164.2.393
• 发表时间: 1986-08-01
• 期刊: The Journal of experimental medicine
• 作者: Pischel KD;Bluestein HG;Woods VL Jr
• 通讯作者: Woods VL Jr

Antineuronal antibodies in systemic lupus erythematosus.

系统性红斑狼疮中的抗神经元抗体。

• DOI: 10.1002/art.1780250711
• 发表时间: 1982
• 期刊: Arthritis and rheumatism
• 作者: Bluestein,HG;WoodsJr,VL
• 通讯作者: WoodsJr,VL

Use of the monoclonal antibody 12F1 to characterize the differentiation antigen VLA-2.

• DOI: 10.4049/jimmunol.138.1.226
• 发表时间: 1987-01
• 期刊: Journal of immunology
• 影响因子: 4.4
• 作者: K. Pischel;M. Hemler;C. Huang;H. Bluestein;V. Woods

Antigenic polymorphism of human very late activation protein-2 (platelet glycoprotein Ia-IIa). Platelet alloantigen Hca.

人极晚激活蛋白-2（血小板糖蛋白 Ia-IIa）的抗原多态性。

• DOI: 10.1172/jci113984
• 发表时间: 1989
• 期刊: The Journal of clinical investigation
• 作者: WoodsJr,VL;Pischel,KD;Avery,ED;Bluestein,HG
• 通讯作者: Bluestein,HG