Convergence in evaluation frameworks for integrated surveillance of AMR (CoEval-AMR)

AMR 综合监测评估框架的趋同 (CoEval-AMR)

• 批准号: MR/S037721/1
• 负责人: Barbara Nicole Haesler
• 金额: $ 4.85万
• 依托单位: Royal Veterinary College
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FS037721%2F1
• 关键词: Convergence; evaluation; frameworks; integrated; surveillance

Antimicrobial resistance (AMR) is the ability of a microorganism (e.g. bacteria, parasites, viruses) to stop responding to an antimicrobial drug (e.g. antibiotics, antiparasitic or antiviral drugs) that previously treated them effectively. As a result, standard treatments become ineffective in people and animals with serious welfare and economic consequences. Resistant microorganisms and genes can be found in humans, animals and the environment. To understand better the evolution, emergence and behaviour of AMR and help informing decision-making for national, regional, and global solutions, it is important to have cost-effective surveillance systems. Surveillance in this context is the continuous, systematic collection, analysis and interpretation of health-related data for health decision-making.Because of the complexity of the problem, various international organisations have called for collaboration across human, animal, and environmental sectors and adoption of a "One Health" approach. Several integrated surveillance strategies exist globally but their effectiveness and economic efficiency remain to be evaluated. Therefore, the aim of the Network "Convergence in evaluation frameworks for integrated surveillance of AMR" is to develop guidance for a harmonised evaluation framework that will address the specific needs of integrated surveillance systems for AMR. The use of this evaluation framework will help to understand what works and does not work in AMR surveillance and thereby help to set up improved, cost-effective surveillance for AMR. To elaborate this evaluation framework, we will bring together international experts in the field who have long-standing experience in surveillance, AMR and/or evaluation. We will organise two main scientific workshops to review and discuss existing evaluation frameworks and approaches. In the process, we will identify gaps and areas for improvements and we will work towards an agreed evaluation framework. In a next step, protocols and written guidance will be developed and made publicly available through an existing online website used for surveillance evaluation (SurvTools: https://survtools.org). Results will allow understanding the value of cross-sectoral, integrated surveillance for AMR, and help policy makers make decisions on how to invest resources for surveillance.

抗菌素耐药性(AMR)是指微生物(如细菌、寄生虫、病毒)对以前有效治疗它们的抗微生物药物(如抗生素、抗寄生虫或抗病毒药物)停止反应的能力。结果，标准治疗对人和动物变得无效，带来严重的福利和经济后果。在人类、动物和环境中都可以找到抗药性微生物和基因。为了更好地了解AMR的演变、出现和行为，并帮助为国家、区域和全球解决方案的决策提供信息，具有成本效益的监测系统非常重要。在这种情况下，监测是对与健康有关的数据进行持续、系统的收集、分析和解释，以供卫生决策之用。由于问题的复杂性，各种国际组织呼吁在人类、动物和环境部门之间进行合作，并采取“同一健康”的方法。全球存在若干综合监测战略，但其效力和经济效率仍有待评估。因此，“综合监测AMR评价框架的趋同”网络的目的是为统一评价框架制定指南，以满足综合监测系统的具体需要。使用这一评估框架将有助于了解在AMR监测中哪些有效，哪些无效，从而有助于建立改进的、具有成本效益的AMR监测。为了阐述这一评估框架，我们将召集该领域的国际专家，他们在监测、AMR和/或评估方面具有长期经验。我们将组织两个主要的科学讲习班，以审查和讨论现有的评价框架和方法。在这一过程中，我们将找出差距和需要改进的领域，并将努力达成一个商定的评价框架。在下一步，将制定协议和书面指导，并通过用于监测评估的现有在线网站(SurvTool：https://survtools.org).)公开提供结果将有助于了解跨部门、综合监测对AMR的价值，并帮助政策制定者就如何投入资源进行监测做出决定。

项目成果

Choosing an evaluation framework for surveillance of antimicrobial resistance and/or antimicrobial use

选择监测抗菌药物耐药性和/或抗菌药物使用的评估框架

• 发表时间: 2020
• 作者: CoEvalAMR-Consortium

Capturing systematically users' experience of evaluation tools for integrated AMU and AMR surveillance.

• DOI: 10.3389/fvets.2023.1107122
• 发表时间: 2023
• 期刊: FRONTIERS IN VETERINARY SCIENCE
• 影响因子: 3.2
• 作者: Alban, Lis;Bordier, Marion;Hasler, Barbara;Collineau, Lucie;Tomassone, Laura;Bennani, Houda;Aenishaenslin, Cecile;Norstrom, Madelaine;Aragrande, Maurizio;Filippitzi, Maria Eleni;Moura, Pedro;Sandberg, Marianne
• 通讯作者: Sandberg, Marianne

Evaluating the Integration of One Health in Surveillance Systems for Antimicrobial Use and Resistance: A Conceptual Framework.

• DOI: 10.3389/fvets.2021.611931
• 发表时间: 2021
• 期刊: Frontiers in veterinary science
• 影响因子: 3.2
• 作者: Aenishaenslin C;Häsler B;Ravel A;Parmley EJ;Mediouni S;Bennani H;Stärk KDC;Buckeridge DL
• 通讯作者: Buckeridge DL

Conference poster: Choosing the appropriate evaluation framework for integrated surveillance of antimicrobial use and resistance - an online guidance

会议海报：为抗菌药物使用和耐药性综合监测选择适当的评估框架 - 在线指南

• 发表时间: 2020
• 作者: Haesler B

Surveillance of antimicrobial use and resistance: How can evaluation information help decision-making?

抗菌药物使用和耐药性的监测：评估信息如何帮助决策？

• 发表时间: 2021
• 作者: Haesler B