CELL CYCLE TARGETS FOR DRUG AND RADIATION SENSITIVITY

药物和辐射敏感性的细胞周期目标

• 批准号: 2686768
• 负责人: WILLIAM G. MCKENNA
• 金额: $ 109.13万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-17 至 2003-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2686768
• 关键词: apoptosis; cell cycle; cellular oncology; molecular oncology; neoplasm /cancer chemotherapy; neoplasm /cancer radiation therapy; radiation sensitivity

The goal of this revised program project is to study cell cycle checkpoint control in the context of the potential for therapeutic intervention. There are three sub-themes: 1) a mechanism and signaling of the DNA damage checkpoints; 2) drug and radiation sensitivity; and 3) apoptosis. This application bring together a group of five basic scientists and clinician- scientists from four departments at the University of Pennsylvania and the Fox Chase Cancer Center. This group represents diverse disciplines involved in oncology, pathology, genetics and molecular and cellular biology. Each member of the group has a strong and established track record in cell cycle research. The proposed program project builds on established interactions and collaborations between the laboratories of each of the scientists. The underlying theme of the project is to understand the molecular pathways for checkpoint control and their relationship to drug and radiation sensitivity. Dissection of the components of these pathways may lead to their exploitation in a clinical setting where drug and radiosensitivities of tumors and normal tissues can be manipulated. The mixture of basic and clinical scientists represented by this project is essential for the integration and focusing on their research efforts on the mechanism by which cells respond to DNA damage. The advantage of having a highly focused group will result in an enhanced "large picture" of the cell's response. The working group involved in the project will facilitate the placement of finding from each laboratory into the context of the overall theme. This will stimulate ideas, and the free flow of materials and information will expand the boundaries of the individual groups There are five proposed projects plus three cores from which all the investigators will draw. The ultimate result of the project will be a better understanding of now radio-therapy and chemotherapy may integrate knowledge of cell cycle checkpoints into the development of new treatment strategies.

这个修订项目的目标是研究细胞周期检查点 在潜在的治疗干预的背景下进行控制。 分三个主题：1)DNA损伤的机制和信号 检查点；2)药物和辐射敏感性；以及3)细胞凋亡。这 应用程序汇集了五名基础科学家和临床医生- 来自宾夕法尼亚大学四个系的科学家和 福克斯·蔡斯癌症中心。这一群体代表不同的学科 涉及肿瘤学、病理学、遗传学以及分子和细胞 生物学。团队中的每个成员都有一条强有力的既定路线 在细胞周期研究中的记录。拟议的方案项目建立在 两个实验室之间已建立的互动和合作 每一位科学家。该项目的基本主题是 了解检查点控制的分子途径及其 与药物和辐射敏感性的关系。对中国传统文化的剖析 这些通路的组成部分可能导致它们在临床上的利用 设置肿瘤和正常组织的药物和放射敏感性 被操控。基础科学家和临床科学家的混合体代表 通过这个项目是必不可少的集成和专注于他们的 对细胞对DNA损伤做出反应的机制的研究。 拥有一个高度专注的团队的优势将导致增强 细胞反应的“大图”。参与此次会议的工作组 该项目将促进将每个实验室的发现放入 总体主题的背景。这将激发人们的想法和自由 物质和信息的流动将扩大 个别小组有五个拟议项目外加三个核心来自 所有的调查员都会画出来。该项目的最终结果是 会对现在的放射治疗和化疗有更好的了解 将细胞周期检查点的知识整合到新的 治疗策略。