CELL CYCLE TARGETS FOR DRUG AND RADIATION SENSITIVITY

药物和辐射敏感性的细胞周期目标

• 批准号: 2686768
• 负责人: WILLIAM G. MCKENNA
• 金额: $ 109.13万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-17 至 2003-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2686768
• 关键词: apoptosis; cell cycle; cellular oncology; molecular oncology; neoplasm /cancer chemotherapy; neoplasm /cancer radiation therapy; radiation sensitivity

The goal of this revised program project is to study cell cycle checkpoint control in the context of the potential for therapeutic intervention. There are three sub-themes: 1) a mechanism and signaling of the DNA damage checkpoints; 2) drug and radiation sensitivity; and 3) apoptosis. This application bring together a group of five basic scientists and clinician- scientists from four departments at the University of Pennsylvania and the Fox Chase Cancer Center. This group represents diverse disciplines involved in oncology, pathology, genetics and molecular and cellular biology. Each member of the group has a strong and established track record in cell cycle research. The proposed program project builds on established interactions and collaborations between the laboratories of each of the scientists. The underlying theme of the project is to understand the molecular pathways for checkpoint control and their relationship to drug and radiation sensitivity. Dissection of the components of these pathways may lead to their exploitation in a clinical setting where drug and radiosensitivities of tumors and normal tissues can be manipulated. The mixture of basic and clinical scientists represented by this project is essential for the integration and focusing on their research efforts on the mechanism by which cells respond to DNA damage. The advantage of having a highly focused group will result in an enhanced "large picture" of the cell's response. The working group involved in the project will facilitate the placement of finding from each laboratory into the context of the overall theme. This will stimulate ideas, and the free flow of materials and information will expand the boundaries of the individual groups There are five proposed projects plus three cores from which all the investigators will draw. The ultimate result of the project will be a better understanding of now radio-therapy and chemotherapy may integrate knowledge of cell cycle checkpoints into the development of new treatment strategies.

该修订计划项目的目标是研究细胞周期检查点 在治疗干预潜力的背景下进行控制。 共有三个子主题：1）DNA 损伤的机制和信号传导 检查站； 2）药物和放射敏感性； 3）细胞凋亡。这 应用程序汇集了五位基础科学家和临床医生组成的小组 - 来自宾夕法尼亚大学四个系的科学家 福克斯蔡斯癌症中心。这个群体代表了不同的学科 涉及肿瘤学、病理学、遗传学以及分子和细胞学 生物学。该团体的每个成员都有强大且既定的轨道 细胞周期研究记录。拟议的计划项目建立在 各实验室之间建立了互动与合作 每个科学家。该项目的基本主题是 了解检查点控制的分子途径及其 与药物和辐射敏感性的关系。解剖 这些途径的组成部分可能导致它们在临床中的利用 肿瘤和正常组织对药物和放射敏感性的环境 被操纵。基础科学家和临床科学家的混合代表 这个项目对于整合和关注它们至关重要 研究细胞对DNA损伤作出反应的机制。 拥有高度集中的团队的优势将导致增强 细胞反应的“大图”。参与该工作的工作组 项目将促进将每个实验室的发现放入 整体主题的背景。这将激发创意和自由 物质和信息的流动将扩大边界 各个小组有五个拟议项目以及三个核心项目 所有调查员都会画出。项目的最终结果 将会更好地了解现在的放疗和化疗可能 将细胞周期检查点的知识整合到新产品的开发中 治疗策略。