CELL CYCLE TARGETS FOR DRUG AND RADIATION SENSITIVITY

药物和辐射敏感性的细胞周期目标

• 批准号: 6159304
• 负责人: WILLIAM G. MCKENNA
• 金额: $ 1.39万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-17 至 2003-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6159304
• 关键词: apoptosis; cell cycle; cellular oncology; molecular oncology; neoplasm /cancer chemotherapy; neoplasm /cancer radiation therapy; radiation sensitivity

The goal of this revised program project is to study cell cycle checkpoint control in the context of the potential for therapeutic intervention. There are three sub-themes: 1) a mechanism and signaling of the DNA damage checkpoints; 2) drug and radiation sensitivity; and 3) apoptosis. This application bring together a group of five basic scientists and clinician- scientists from four departments at the University of Pennsylvania and the Fox Chase Cancer Center. This group represents diverse disciplines involved in oncology, pathology, genetics and molecular and cellular biology. Each member of the group has a strong and established track record in cell cycle research. The proposed program project builds on established interactions and collaborations between the laboratories of each of the scientists. The underlying theme of the project is to understand the molecular pathways for checkpoint control and their relationship to drug and radiation sensitivity. Dissection of the components of these pathways may lead to their exploitation in a clinical setting where drug and radiosensitivities of tumors and normal tissues can be manipulated. The mixture of basic and clinical scientists represented by this project is essential for the integration and focusing on their research efforts on the mechanism by which cells respond to DNA damage. The advantage of having a highly focused group will result in an enhanced "large picture" of the cell's response. The working group involved in the project will facilitate the placement of finding from each laboratory into the context of the overall theme. This will stimulate ideas, and the free flow of materials and information will expand the boundaries of the individual groups There are five proposed projects plus three cores from which all the investigators will draw. The ultimate result of the project will be a better understanding of now radio-therapy and chemotherapy may integrate knowledge of cell cycle checkpoints into the development of new treatment strategies.

这个修订后的程序项目的目标是研究单元周期检查点 控制治疗干预的潜力。 有三个子主题：1）DNA损伤的机理和信号传导 检查点； 2）药物和辐射敏感性； 3）凋亡。这 应用汇集了一组由五位基本科学家和临床医生组成的 宾夕法尼亚大学四个系的科学家和 福克斯大通癌中心。该小组代表多样化的学科 参与肿瘤学，病理学，遗传学以及分子和细胞 生物学。该小组的每个成员都有很强而建立的轨道 记录细胞周期研究。拟议的计划项目以 建立的互动以及实验室之间的合作 每个科学家。该项目的基本主题是 了解检查点控制及其的分子途径 与药物和辐射敏感性的关系。解剖 这些途径的组成部分可能会导致其在临床上的剥削 设置肿瘤和正常组织的药物和放射敏性可以 被操纵。基本科学家和临床科学家的混合物代表 通过这个项目，对整合和关注他们的关注至关重要 研究细胞对DNA损伤反应的机制的研究工作。 拥有高度专注的群体的优势将导致增强 细胞反应的“大图”。参与的工作组 项目将有助于从每个实验室发现的位置 总体主题的背景。这将刺激想法和自由 材料和信息的流将扩大 各个团体有五个拟议的项目以及三个核心 所有调查人员都会吸引哪些。项目的最终结果 现在可以更好地理解现在的放射治疗和化学疗法 将细胞周期检查点的知识整合到新的开发中 治疗策略。