MECHANISMS OF CELL PROLIFERATION FOLLOWING PERTURBATIONS

扰动后细胞增殖的机制

基本信息

  • 批准号:
    6269873
  • 负责人:
  • 金额:
    $ 15.22万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1998
  • 资助国家:
    美国
  • 起止时间:
    1998-07-01 至 1999-06-30
  • 项目状态:
    已结题

项目摘要

The objective of the proposed research is to determine the mechanisms of acceleration in G 1- transit following a reversible block of cell cycle progression in S-phase of the preceding generation. A possible mechanism for this phenomenon is that delayed progression in S-phase can trigger biochemical processes pertinent to the subsequent G 1-phase prior to the completion of mitosis. In Specific Aim 1, we will determine if cell cycle perturbations that lead to G 1- acceleration in HeLa cells have similar effects in other human cell lines of both normal and transformed phenotypes. Detailed kinetic analyses will be used to completely map the competence window, i.e., the cell cycle time between early S and M phases in which delayed progression results in G 1- acceleration. In Specific Aim 2, will determine if accelerated G 1 transit is due to an alteration in the expression of known G 1- regulatory proteins. The work proposed in Specific Aim 3 will determine whether accelerated G 1-transit following S-phase perturbation results in an unscheduled inactivation of the Retinoblastoma protein and determine, whether such a mechanism can abrogate the ionizing radiation-induced G 1-arrest. In Specific Aim 4 we will determine which specific mRNA species contribute to the altered expression of G 1-regulatory proteins observed in Aim 2 which are associated with G 1-acceleration. The results obtained from completion of this study will characterize the mechanisms involved in recover from cell-cycle perturbation, and verify the idea that early G1 events can be influenced by biochemical processes occurring prior to the completion of mitosis.
拟议研究的目的是确定

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Prabhat C Goswami其他文献

54 - An Age-Associated Decline in Fibroblast Antioxidant Capacity Promotes Epithelial Cancer Cell Proliferation
  • DOI:
    10.1016/j.freeradbiomed.2014.10.449
  • 发表时间:
    2014-11-01
  • 期刊:
  • 影响因子:
  • 作者:
    John T Lafin;Ehab H Sarsour;Wusheng Xiao;Amanda L Kalen;Prabhat C Goswami
  • 通讯作者:
    Prabhat C Goswami
PSS316 - Selenoprotein P Regulates Environmental Pollutant PCB-Induced Oxidative Stress and Toxicity in Human Keratinocytes
  • DOI:
    10.1016/j.freeradbiomed.2013.10.740
  • 发表时间:
    2013-11-01
  • 期刊:
  • 影响因子:
  • 作者:
    Wusheng Xiao;Yueming Zhu;Ehab H Sarsour;Amanda L Kalen;Nukhet Aykin-Burns;Douglas R Spitz;Prabhat C Goswami
  • 通讯作者:
    Prabhat C Goswami
An Inverse Correlation Between Manganese Superoxide Dismutase Activity and Glucose Consumption: MnSOD, a New Molecular Player for the Warburg Effect
  • DOI:
    10.1016/j.freeradbiomed.2010.10.169
  • 发表时间:
    2010-01-01
  • 期刊:
  • 影响因子:
  • 作者:
    Ehab H Sarsour;Amanada L Kalen;Zhen Xiao;Leena Chaudhuri;Timothy D Veenstra;Prabhat C Goswami
  • 通讯作者:
    Prabhat C Goswami
291 - Increased DNA Damage and Reactive Oxygen Species Mediate Age-Associated Differential Susceptibility of Normal Dermal Fibroblasts to Chemotherapy and Radiation
  • DOI:
    10.1016/j.freeradbiomed.2015.10.340
  • 发表时间:
    2015-10-01
  • 期刊:
  • 影响因子:
  • 作者:
    Kranti A Mapuskar;Joshua D Schoenfeld;Zita A Sibenaller;Dennis P Riley;Stephan Strack;Prabhat C Goswami;John M Buatti;Douglas R Spitz;Bryan G Allen
  • 通讯作者:
    Bryan G Allen

Prabhat C Goswami的其他文献

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{{ truncateString('Prabhat C Goswami', 18)}}的其他基金

Antioxidant Enzymes and Cell Cycle Checkpoint Pathways
抗氧化酶和细胞周期检查点途径
  • 批准号:
    7102437
  • 财政年份:
    2006
  • 资助金额:
    $ 15.22万
  • 项目类别:
Redox Biology of Quiescent Normal Fibroblasts and Epithelial Cancer Progression
静止正常成纤维细胞的氧化还原生物学和上皮癌进展
  • 批准号:
    8677737
  • 财政年份:
    2006
  • 资助金额:
    $ 15.22万
  • 项目类别:
Antioxidant Enzymes and Cell Cycle Checkpoint Pathways
抗氧化酶和细胞周期检查点途径
  • 批准号:
    7569029
  • 财政年份:
    2006
  • 资助金额:
    $ 15.22万
  • 项目类别:
Redox Biology of Quiescent Normal Fibroblasts and Epithelial Cancer Progression
静止正常成纤维细胞的氧化还原生物学和上皮癌进展
  • 批准号:
    8371105
  • 财政年份:
    2006
  • 资助金额:
    $ 15.22万
  • 项目类别:
Antioxidant Enzymes and Cell Cycle Checkpoint Pathways
抗氧化酶和细胞周期检查点途径
  • 批准号:
    7347523
  • 财政年份:
    2006
  • 资助金额:
    $ 15.22万
  • 项目类别:
Antioxidant Enzymes and Cell Cycle Checkpoint Pathways
抗氧化酶和细胞周期检查点途径
  • 批准号:
    7758291
  • 财政年份:
    2006
  • 资助金额:
    $ 15.22万
  • 项目类别:
Antioxidant Enzymes and Cell Cycle Checkpoint Pathways
抗氧化酶和细胞周期检查点途径
  • 批准号:
    7225211
  • 财政年份:
    2006
  • 资助金额:
    $ 15.22万
  • 项目类别:
Redox Biology of Quiescent Normal Fibroblasts and Epithelial Cancer Progression
静止正常成纤维细胞的氧化还原生物学和上皮癌进展
  • 批准号:
    8518253
  • 财政年份:
    2006
  • 资助金额:
    $ 15.22万
  • 项目类别:
MECHANISMS OF CELL PROLIFERATION FOLLOWING PERTURBATIONS
扰动后细胞增殖的机制
  • 批准号:
    6320825
  • 财政年份:
    2000
  • 资助金额:
    $ 15.22万
  • 项目类别:
MECHANISMS OF CELL PROLIFERATION FOLLOWING PERTURBATIONS
扰动后细胞增殖的机制
  • 批准号:
    6103417
  • 财政年份:
    1999
  • 资助金额:
    $ 15.22万
  • 项目类别:

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Elucidation of cell cycle dependence of ferrotosis and active oxygen production pathway caused by cell proliferation
阐明细胞增殖引起的铁死亡和活性氧产生途径的细胞周期依赖性
  • 批准号:
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ERK1/2 信号如何驱动细胞增殖和细胞周期停滞?
  • 批准号:
    2493293
  • 财政年份:
    2018
  • 资助金额:
    $ 15.22万
  • 项目类别:
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The function of truncated MEK1 protein in a G2 phase cell cycle delay and in mitosis. Understanding cell proliferation.
截短的 MEK1 蛋白在 G2 期细胞周期延迟和有丝分裂中的功能。
  • 批准号:
    DP0771404
  • 财政年份:
    2007
  • 资助金额:
    $ 15.22万
  • 项目类别:
    Discovery Projects
Gastrointestinal Cell Proliferation and Cell Cycle
胃肠细胞增殖和细胞周期
  • 批准号:
    6922525
  • 财政年份:
    2005
  • 资助金额:
    $ 15.22万
  • 项目类别:
Gastrointestinal Cell Proliferation and Cell Cycle
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  • 批准号:
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    2005
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    $ 15.22万
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Elf/Smad4 in Gastrointestinal Cell Proliferation and Cell Cycle Progression
Elf/Smad4 在胃肠道细胞增殖和细胞周期进展中的作用
  • 批准号:
    7425327
  • 财政年份:
    2005
  • 资助金额:
    $ 15.22万
  • 项目类别:
Elf/Smad4 in Gastrointestinal Cell Proliferation and Cell Cycle Progression
Elf/Smad4 在胃肠道细胞增殖和细胞周期进展中的作用
  • 批准号:
    7244447
  • 财政年份:
    2005
  • 资助金额:
    $ 15.22万
  • 项目类别:
Gastrointestinal Cell Proliferation and Cell Cycle
胃肠细胞增殖和细胞周期
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  • 财政年份:
    2005
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  • 项目类别:
Gastrointestinal Cell Proliferation and Cell Cycle
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    7067214
  • 财政年份:
    2005
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    $ 15.22万
  • 项目类别:
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CD151 (PETA-3) 在人类肿瘤中的预后价值及其在细胞增殖、运动和细胞周期中的作用
  • 批准号:
    nhmrc : 310619
  • 财政年份:
    2004
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  • 项目类别:
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