GASTROINTESTINAL PROGRAM PROJECT

建议对结直肠癌和胰腺癌进行研究。它把它当作它的 以下模型为主题：细胞与DNA损伤的相互作用 药物可以产生三类细胞--DNA完整的正常细胞； DNA受损的细胞发生凋亡；而细胞，尽管 DNA损伤，自杀失败。我们建议探讨 这三类细胞的差异，以增加我们的理解 以监测干预措施，确定标记物 可用于人群筛查，并可用于治疗 目的。 项目1重点研究了高危人群中的氧化损伤和细胞凋亡 人类群体-患有胰腺炎-和一个动物模型 确定氧化DNA损伤和抗氧化剂在 胰腺炎和胰腺癌，并开发一种临床筛查 测试。项目2还专注于一种高风险的炎症性疾病- 溃疡性结肠炎--为了确定DNA损伤和 突变在UC异型增生进展中的作用此外，一个 建议使用抗氧化剂进行干预，以逆转或减缓 异型增生、瘤变序列。项目3专注于结肠镜检查患者 具体目的是确定路径中的几个过程，以实现 肿瘤，包括氧化损伤和表达的变化 与细胞凋亡相关的蛋白，这将使早期识别 以低成本、微创的方式对高危个体进行治疗。

Research in colorectal and pancreas cancer is proposed. It takes as its theme the following model: the interaction of cells with DNA damaging agents can result in three classes of cells-normal cells with intact DNA; cells with damaged DNA that undergo apoptosis; and cells which, despite DNA damage, fail to suicide. We propose to explore aspects of the differences in these three classes of cells to increase our understanding of the carcinogenesis process, to monitor interventions, identify markers that may be used for population screening, and to exploit for therapeutic purposes. Project 1 focuses on oxidative damage and apoptosis among a high-risk human populations- with pancreatitis- and an animal model in order to establish the roles of oxidative DNA damage and antioxidants in pancreatitis and pancreas cancer, and to develop a clinical screening test. Project 2 also focuses on a high-risk inflammatory disease- ulcerative colitis-in order to determine the role of DNA damage and mutagenesis in the progression of UC dysplasia. In addition, an intervention with antioxidants is proposed to reverse of slow the dysplasia neoplasia sequence. Project 3 focuses on colonoscopy patients with the specific aim of identifying several processes in the pathways to neoplasia, including oxidative damage and changes in expression of apoptosis-related proteins, that will allow the early identification of high-risk individuals in a low-cost, minimally invasive manner.