RELEVANCE OF CHEMICALLY INDUCED FORESTOMACH NEOPLASMS IN B6C3F1 MOUSE

工作总结：突变谱提供 有助于了解诱变潜在机制的信息 和致癌作用。我们将检查诱发的前胃肿瘤 由一类致癌物质(氯丁二烯、异戊二烯和1，3-丁二烯) 激活ras基因的突变。然后，这些信息将会 与已知的外源基因突变特性有关 内源性诱导的DNA加合物提供信息 关于不同加成词的关联性。因为这些致癌物质 多个部位的诱发肿瘤，另一个部位的突变谱 部位将与前胃的部位进行比较，以确定 是否涉及类似的机制。

Summary of Work: Mutational spectra provide information to help understand mechanisms underlying mutagenesis and carcinogenesis. We will examine forestomach tumors induced by a class of carcinogens (chloroprene, isoprene, and 1,3-butadiene) for activating mutations of the ras gene. This information will then be related to the known mutagenic properties of exogenously andendogenously- induced DNA adducts to provide information about the relevance of different adducts. Since these carcinogens induced tumors at multiple sites, mutational spectra for the other sites will be compared to that for the forestomach to determine whether a similar mechanism is involved.