MRM OF BRAIN LESIONS FOLLOWING CARBONYL SULFIDE EXPOSURE

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。本研究的目的是证明磁共振显微镜在F344大鼠暴露于清洁空气化学物质羰基硫化物（COS）后的神经病理学特征方面的效用。羰基硫化物被环境保护署提名到国家毒理学计划进行毒性测试。此外，由于报告的高排放量（每年9500吨）和缺乏动物研究，COS被列入《清洁空气法》化学品清单。本研究将为保护人体健康提供必要的毒性和机理数据。选择COS作为研究类型的代表，将有利于NIEHS评估固定组织（MR组织学）和活体动物（纵向）研究的神经病理学。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this research is to demonstrate the utility of magnetic resonance microscopy in characterizing the neuropathology findings in F344 rats following exposure to the clean air chemical, carbonyl sulfide (COS). Carbonyl sulfide was nominated to the National Toxicology Program for toxicity testing by the Environmental Protection Agency. Furthermore COS was included on the clean air act chemical list because of reported high emissions (9500 tons/yr) and lack of animal studies. This study will provide the necessary toxicity and mechanistic data for the protection of human health. COS has been chosen as representative of the types of studies that would be beneficial to NIEHS in assessing neuropathology in both fixed tissues (MR Histology) and live animal (longitudinal) studies.