INHALATION TOXICITY OF VOLATILE ORGANIC CHEMICALS--CARBON DISULFIDE

在过去十年中，公众和科学界对慢性神经退行性疾病的认识急剧上升，最近随着知名人士披露他们的神经系统疾病及其与环境化学物质的潜在联系，公众和科学意识达到了前所未有的高度。公众担心二硫化碳的潜在神经毒性。目标是提供关于二硫化碳（CS2）如何影响人类健康的更好的机制数据。另一个目标是在神经毒性研究中提供神经系统完整性的详细描述。神经毒性指南的一个共同主题是，所有可获得的数据应该综合起来，以提供任何可能的神经毒性危害的连贯描述。监管机构高度重视这一综合图景，因为他们有责任评估和管理与复杂神经系统相关的风险。评估需要整合来自神经学、行为学、电生理和病理终点的数据。研究是通过内部吸入动物研究完成的，并通过与当地大学科学家和环境保护局科学家的合作努力继续进行。正在评估大鼠和小鼠之间的中枢神经系统比较研究。

Summary of Work: Public and scientific awareness of chronic neurodegenerative disease has risen dramatically during the last decade and recently reached an all time high with the disclosure by well-known individuals of their nervous system maladies and the potential association with environmental chemicals. The public is concerned about the potential neurotoxicity of carbon disulfide. The goal is to provide better mechanistic data on how carbon disulfide (CS2) can affect human health. Another goal is to provide detailed descriptions of the nervous system integrity during neurotoxicity studies. A common theme among neurotoxicity guidelines is that all available data should be integrated to provide a coherent description of any possible neurotoxic hazards. This integrated picture is valued highly by regulators who have the responsibility for assessing and managing risk connected with the complex nervous system. The assessment requires integration of data from neurological, behavioral, electrophysiological and pathological endpoints. Research was accomplished through in-house inhalation animal studies and is being continued through collaborative efforts with scientists at local universities and with EPA scientists. Comparative central nervous system studies between the rat and mouse are being evaluated.