Manganese Enhanced Magnetic Resonance Imaging (MRI) in Ischaemic and Takotsubo Cardiomyopathy.

锰增强磁共振成像 (MRI) 在缺血性和 Takotsubo 心肌病中的应用。

• 批准号: MR/T029153/1
• 负责人: Trisha Singh
• 金额: $ 29.81万
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FT029153%2F1
• 关键词: Manganese; Enhanced; Magnetic; Resonance; Imaging

Scanning the heart using magnetic resonance imaging (MRI) enables detailed assessment of its structure and function. MRI can give more detailed information about the heart by using a contrast 'dye' that is injected into a vein during the scan. This can highlight abnormal areas within the heart. Current contrast dyes help identify scarring within the heart. Recent studies using a new contrast dye containing manganese has been used in patients with diseased heart arteries (ischemic heart disease) and cardiac conditions affecting the heart muscle (cardiomyopathy). This has shown abnormal uptake of the dye in patients with ischemic heart disease and various cardiomyopathies. It has also shown advantages over traditional contrast; firstly, it can measure the amount of scar more accurately and secondly it can quantify scar.Heart failure is a condition in which the heart muscle is weakened and pumping function is reduced. It is caused by various conditions including different heart muscle diseases and those affecting the heart arteries. Heart failure is a global pandemic affecting at least 26 million people worldwide. Despite the significant advances in therapies and prevention, mortality and morbidity are still high and quality of life poor. Heart failure imposes both direct and indirect costs to healthcare systems and has a significant impact on global health. We plan to further test this manganese containing dye as we believe it will provide better understanding into reversible cardiac conditions. Our study will be conducted in the Queen's Medical Research Institute (QMRI) at the Royal Infirmary Edinburgh led by Dr Trisha Singh. This is a clinical study which will involve using this new contrast agent to scan three patient groups; i) heart attacks by a blocked heart artery (ii) heart disease caused mismatch in blood supply and demand (angina) (iii) heart disease secondary to a stress response (takotsubo). We will scan healthy volunteers for comparison. We believe this new agent has potential to better measure disease in the heart, improve our ability to establish the cause of heart disease and help monitor the disease over time as well as guide future treatment for individual patients. This has the potential to change clinical practice and make an impact on patient care.

使用磁共振成像（MRI）扫描心脏可以详细评估其结构和功能。MRI可以通过在扫描过程中注入静脉的对比“染料”提供有关心脏的更详细信息。这可以突出心脏内的异常区域。目前的造影剂有助于识别心脏内的疤痕。最近的研究使用一种新的造影剂含锰已被用于患者的心脏动脉病变（缺血性心脏病）和心脏疾病影响心肌（心肌病）。这表明在患有缺血性心脏病和各种心肌病的患者中染料的异常摄取。它也显示出优于传统对比的优势;首先，它可以更准确地测量疤痕的数量，其次，它可以量化疤痕。心力衰竭是一种心肌衰弱和泵血功能降低的情况。它是由各种疾病引起的，包括不同的心肌疾病和影响心脏动脉的疾病。心力衰竭是一种全球性流行病，影响全球至少2600万人。尽管在治疗和预防方面取得了重大进展，但死亡率和发病率仍然很高，生活质量很差。心力衰竭给医疗保健系统带来直接和间接成本，并对全球健康产生重大影响。我们计划进一步测试这种含锰染料，因为我们相信它将更好地了解可逆性心脏病。我们的研究将在爱丁堡皇家医院的女王医学研究所（QMRI）进行，由Trisha Singh博士领导。这是一项临床研究，将涉及使用这种新的造影剂扫描三组患者：i）心脏动脉阻塞引起的心脏病发作（ii）血液供需不匹配引起的心脏病（心绞痛）（iii）继发于应激反应的心脏病（takotsubo）。我们将扫描健康志愿者进行比较。我们相信这种新药物有潜力更好地测量心脏疾病，提高我们确定心脏病病因的能力，并随着时间的推移帮助监测疾病，并指导未来对个体患者的治疗。这有可能改变临床实践，并对患者护理产生影响。

项目成果

Emerging molecular imaging targets and tools for myocardial fibrosis detection.

• DOI: 10.1093/ehjci/jeac242
• 发表时间: 2023-02-17
• 期刊: European heart journal. Cardiovascular Imaging

Reproducibility of quantitative plaque measurement in advanced coronary artery disease.

晚期冠状动脉疾病中定量斑块测量的可重复性。

• DOI: 10.1016/j.jcct.2020.12.008
• 发表时间: 2021-07
• 期刊: Journal of cardiovascular computed tomography
• 影响因子: 5.4
• 作者: Meah MN;Singh T;Williams MC;Dweck MR;Newby DE;Slomka P;Adamson PD;Moss AJ;Dey D
• 通讯作者: Dey D

Repeatability and reproducibility of cardiac manganese-enhanced magnetic resonance imaging.

• DOI: 10.1038/s41598-023-29591-z
• 发表时间: 2023-02-27
• 期刊: SCIENTIFIC REPORTS
• 影响因子: 4.6
• 作者: Singh, T.;Joshi, S.;Meah, M. N.;Spath, N. B.;Papanastasiou, G.;Kershaw, L. E.;Baker, A. H.;Dweck, M. R.;Newby, D. E.;Semple, S. I.
• 通讯作者: Semple, S. I.

Validation of European Society of Cardiology pre-test probabilities for obstructive coronary artery disease in suspected stable angina.

欧洲心脏病学学会的验证预测冠状动脉疾病的预测试概率可疑稳定心绞痛。

• DOI: 10.1093/ehjqcco/qcaa006
• 发表时间: 2020-10-01
• 期刊: European heart journal. Quality of care & clinical outcomes
• 作者: Bing R;Singh T;Dweck MR;Mills NL;Williams MC;Adamson PD;Newby DE
• 通讯作者: Newby DE

Is the fear of disease worse than the disease itself?

对疾病的恐惧比疾病本身更严重吗？

• DOI: 10.1136/heartjnl-2020-318207
• 发表时间: 2021
• 期刊: Heart
• 影响因子: 5.7
• 作者: Singh T