Repeatability and reproducibility of cardiac manganese-enhanced magnetic resonance imaging.
Repeatability and reproducibility of cardiac manganese-enhanced magnetic resonance imaging.
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DOI：
10.1038/s41598-023-29591-z
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发表时间：
2023-02-27
影响因子：
4.6
通讯作者：
Semple, S. I.
中科院分区：
文献类型：
--
作者：
Singh, T.;Joshi, S.;Meah, M. N.;Spath, N. B.;Papanastasiou, G.;Kershaw, L. E.;Baker, A. H.;Dweck, M. R.;Newby, D. E.;Semple, S. I.
锰增强磁共振成像可以提供心肌钙处理的替代测量。其可重复性和再现性目前尚不清楚。68名参与者：20名健康志愿者，20名急性心肌梗死，18名肥厚性心肌病和10名非缺血性扩张性心肌病进行了锰增强磁共振成像。10名健康志愿者在3个月时重新扫描。评估原生T1值和心肌锰摄取在观察者内部和观察者之间的可重复性。在10名健康志愿者中评估了扫描-扫描的再现性。在健康志愿者中，观察者内和观察者间的平均原生T1映射[林氏相关系数（LCC）分别为0.97和0.97]和心肌锰摄取（LCC分别为0.99和0.96）具有极好的相关性。原生T1和心肌锰摄取的扫描扫描相关性也很好。同样，急性心肌梗死（LCC分别为0.97和0.97）、肥厚（LCC分别为0.98和0.97）和扩张型心肌病（LCC分别为0.99和0.95）患者的原生T1和心肌锰摄取的观察者内相关性也很好。扩张型心肌病患者的一致性范围更广。锰增强磁共振成像在健康心肌中具有较高的重复性和再现性，在病变心肌中具有较高的重复性。然而，需要进一步的研究来建立弥漫性心肌纤维化病理的稳健性。
Manganese-enhanced magnetic resonance imaging can provide a surrogate measure of myocardial calcium handling. Its repeatability and reproducibility are currently unknown. Sixty-eight participants: 20 healthy volunteers, 20 with acute myocardial infarction, 18 with hypertrophic and 10 with non-ischemic dilated cardiomyopathy underwent manganese-enhanced magnetic resonance imaging. Ten healthy volunteers were re-scanned at 3 months. Native T1 values and myocardial manganese uptake were assessed for intra and inter-observer repeatability. Scan-rescan reproducibility was assessed in ten healthy volunteers. Intra-observer and inter-observer correlation was excellent in healthy volunteers for mean native T1 mapping [Lin’s correlation coefficient (LCC) 0.97 and 0.97 respectively] and myocardial manganese uptake (LCC: 0.99 and 0.96 respectively). Scan-rescan correlation for native T1 and myocardial manganese uptake was also excellent. Similarly, intra-observer correlations for native T1 and myocardial manganese uptake in patients with acute myocardial infarction (LCC: 0.97 and 0.97 respectively), hypertrophic (LCC: 0.98 and 0.97 respectively) and dilated cardiomyopathy (LCC: 0.99 and 0.95 respectively) were excellent. Limits of agreement were broader in patients with dilated cardiomyopathy. Manganese-enhanced magnetic resonance imaging has high repeatability and reproducibility in healthy myocardium and high repeatability in diseased myocardium. However, further study is needed to establish robustness in pathologies with diffuse myocardial fibrosis.
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