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ACQUISITION OF A 400 MHZ NMR SPECTROMETER FOR RESEARCH

购买 400 MHZ 核磁共振波谱仪用于研究

基本信息

批准号：
2503787
负责人：
BRUCE GANEM
金额：
$ 33万
依托单位：
CORNELL UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
起止时间：
1998-05-20 至 1999-05-19
项目状态：
已结题

项目摘要

This proposal is a request for the funds required to purchase a 400 MHz NMR spectrometer to expand and update current capabilities in NMR instrumentation at Cornell University. The requested spectrometer will be devoted to structural studies of small molecules in liquids and will provide modern techniques to a core group of NIH-supported users. The spectrometer will be housed in the Chemistry Department NMR Facility, which provides instrumentation and training to almost 200 students and researchers from the university community and local industry. Five NIH- funded Cornell faculty members require access to this spectrometer to carry out a variety of health-related projects. Professor B. Ganem (Principal Investigator) will study (1) potential inhibitors of chorismate mutase/prephenate dehydratase involved in the shikimic acid pathway, (2) the synthesis of glycosidase inhibitors, (3) the synthesis of purine nucleoside phosphorylase inhibitors important for the treatment of AIDS, and (4) inhibitors of glutathione and trypanothione reductases. Professor T. Begley will investigate enzyme function and mechanism by using NMR spectroscopy to elucidate the structure of products of enzyme-catalyzed reactions. These reactions include the (6) thiamin biosythetic pathway, (7) enzymatic repair of UV-irradiated DNA in bacterial spores, (8) the mechanism and inhibition of prolyl-4- hydroxylase, and (9) the biosynthesis of taxol. Professor J. Clardy will investigate natural products from novel sources including (10) anticancer compounds isolated from endophytic fungi and (11) compounds displaying antibiotic properties toward the plant pathogens responsible for fire blight. Professor D. B. Collum will investigate (5) organolithium solvation and aggregation using 6 Li-detected triple- resonance spectroscopy. Professor J. Meinwald will continue to pioneer the field of chemical ecology by exploring (12) biologically active compounds isolated from insect sources.

该提案要求提供购买400 MHz 核磁共振光谱仪可扩展和更新核磁共振的当前功能康奈尔大学的仪器。请求的光谱仪将致力于液体中小分子的结构研究，为NIH支持的核心用户群提供现代技术。的光谱仪将被安置在化学系NMR设施中，为近200名学生提供仪器和培训，来自大学社区和当地工业界的研究人员。五个国家卫生研究院- 受资助的康奈尔大学教职员工需要使用这台光谱仪，开展各种与健康有关的项目。B教授。Ganem （主要研究者）将研究（1）潜在抑制剂与莽草酸有关的分支酸酯酶/预苯酸酯酶途径，（2）糖苷酶抑制剂的合成，（3）嘌呤核苷磷酸化酶抑制剂的重要性治疗艾滋病，和（4）谷胱甘肽和锥虫硫酮的抑制剂还原酶T教授贝格利将研究酶的功能，通过使用NMR光谱来阐明酶催化反应的产物。这些反应包括（6）硫胺素生物合成途径，（7）紫外线照射DNA的酶修复（8）脯氨酰-4- （9）紫杉醇的生物合成。 J. Clardy教授将研究来自新来源的天然产物，包括（10）从内生真菌中分离的抗癌化合物和（11）化合物对植物病原体表现出抗生素特性治疗火疫病 D教授B。第1055章：哥伦会调查的（5）有机锂溶剂化和聚集使用6锂检测三重- 共振光谱学 J·迈因瓦尔德教授将继续开拓化学生态学领域通过探索（12）生物活性从昆虫来源分离的化合物。