500MHz Console Upgrade

描述(由申请人提供)：在这份建议书中，我们要求对瓦里安联营公司制造的Unity 500 MHz核磁共振光谱仪进行控制台升级。Unity 500已经过时了三代，其性能不再满足该设施内大多数NIH用户的需求。此次升级将提高当前仪器的灵敏度、分辨率和可靠性，允许进行更复杂的实验和更高的用户吞吐量。核磁共振设施已经存在了30年，由一名博士级别的专业核磁共振光谱学家担任主任，在用户培训、仪器维护和监督方面有着长期的记录。Unity 500 MHz仪器的用户群主要由拥有NIH持续支持记录的教职员工组成。除了主要用户，康奈尔大学目前有三个小用户，他们的群体是年轻的，他们的PI最终将依赖NIH的支持。这些个人和他们的学生将使用所要求的仪器进行广泛的与健康有关的项目。B.Ganem教授(PI)正在研究基于天然产物COTC的新的合成前药的设计，该药物将专门针对前列腺组织，以及新的糖鞘糖脂代谢抑制剂的合成；T.P.Begley教授将利用该仪器研究修饰的酶底物、设计的抑制剂、产品和机械探针；J.Clardy教授正在研究具有抗癌、抗病毒和抗生素活性的真菌代谢物；B.R.Crane教授的目标是了解蛋白质结构如何控制生物催化和信号转导中的氧化还原和光化学。G.W.Coates教授将研究合成用于生物医学的结构明确的可生物降解聚合物的新方法；D.B.Collum教授将使用核磁共振研究有机锂的溶剂化和聚集态，以获得对合成有用的锂试剂的新见解；D.T.McQuade教授将使用核磁共振技术设计高官能化聚合物的新合成方法；J.Meinwald教授将研究参与化学通信的具有生物意义的分子结构。

DESCRIPTION (provided by applicant): In this proposal we request a console upgrade for a Unity 500 MHz NMR Spectrometer manufactured by Varian Associates. The Unity 500 is three generations out of date and the performance no longer meets the needs of the majority of NIH users within the facility. The upgrade will improve the sensitivity, resolution, and reliability of the current instrument allowing for more sophisticated experiments and higher user throughput. The NMR Facility, which has been in existence for 30 years with a Ph.D. level professional NMR spectroscopist as Director, has a long track record of user training, instrument maintenance, and supervision. The Unity 500 MHz instrument user base consists mostly of faculty with a record of continuous NIH support. Beyond the major users, Cornell currently has three minor users whose groups are young and whose PIs will eventually rely on NIH support. These individuals and their students will use the requested instrumentation for a wide range of health-related projects. Professor B. Ganem (PI) is studying the design of new synthetic prodrugs based on the natural product COTC, which would be targeted specifically to prostate tissue, as well as on the synthesis of new inhibitors of glycosphingolipid metabolism; Professor T.P. Begley will use the instrumentation to study modified enzyme substrates, designed inhibitors, products and mechanistic probes; Professor J. Clardy is investigating fungal metabolites exhibiting anticancer, antiviral, and antibiotic activity; Professor B.R. Crane aims to understand how protein structure controls redox- and photochemistry in biological catalysis and signal transduction. Professor G.W. Coates will investigate new methods for the synthesis of architecturally well-defined biodegradable polymers for biomedical use; Prof. D.B. Collum is investigating organolithium solvation and aggregation states using NMR to obtain new insights into synthetically useful lithium reagents; Professor D.T. McQuade will use NMR in designing new synthetic approaches to highly functionalized polymers; Prof. J. Meinwald will investigate the structures of biologically significant molecules involved in chemical communication.