GENETIC BASIS OF SPECIES DIFFERENCES IN DROSOPHILA

本项目的长期目标是了解 通过对密切相关物种的遗传分析进行物种形成。 我们将 使用经典的遗传方法来揭示数量的位置， 导致果蝇物种之间交配歧视的基因， 产生表皮碳氢化合物种间差异的基因， 作为雌性交配的信息素 将此类技术应用于 各种各样的果蝇群体将帮助我们回答以下问题： 1. 交配歧视和表皮碳氢化合物的差异 近缘物种由于只有一个或几个基因的大的影响， 或涉及几个到多个基因。 2. 在基因组中，导致这些生殖形式的基因座在哪里？ 隔离？ 在不同的物种中它们是否位于相似的区域 一个群体的成对，意味着物种形成的遗传“热点”？ 3. 男性和女性的性隔离是否具有相似的遗传性 基础，或者是不同的基因涉及两种性别？ 4. 性隔离的遗传模式是否一致， 信息素碳氢化合物，适用于几个群体？ 5. 与择偶歧视有关的基因是否集中在 性染色体，1导致杂种不育和不成活的染色体 6. 表皮碳氢化合物在两性间的性隔离中起什么作用 物种？ 尽管性隔离是物种形成的最有力的原因之一， 我们对它的遗传基础几乎一无所知。 这些研究将 为了解物种起源和物种提供重要数据， 激发了新的物种形成理论 的精细结构映射 导致生殖隔离的基因最终会促进他们 分子鉴定，这需要完全了解 物种形成 我们的研究结果可能有助于理解 其他动物，包括人类。

The long-term goal of this project is to understand the process of speciation through genetic analysis of closely-related species. We will use classical genetic methods to reveal the number locations, and effects of genes causing mating discrimination between Drosophila species as of genes producing interspecific differences in cuticular hydrocarbons, which serve as female matting pheromone. Applying such techniques to a variety of Drosophila groups will help us answer the following questions: 1. Are mating discrimination and cuticular-hydrocarbon differences among closely-related species due to only one or a few genes of large effect, or are several to many genes involves. 2. Where in the genome are the loci causing these forms of reproductive isolation? Are they located in similar regions among different species pairs of a group, implying genetic "hotspots" of speciation? 3. Dose sexual isolation among males and females have a similar genetic basis, or are different genes involved in the two sexes? 4. Are there consistent patterns to the genetics of sexual isolation and pheromonal hydrocarbon that apply across several groups?. 5. Are the genes involved in mating discrimination concentrated on the sex chromosomes, 1 those causing hybrid sterility and inviability 6. What role cuticular hydrocarbons play in sexual isolation between species? Although sexual isolation is one of the most potent causes of speciation, we know virtually not about its genetic basis. These studies will provide data important for understanding the origin and species and in motivating new theories of speciation. The fine-structure mapping of genes cause reproductive isolation will eventually facilitate their molecular identification, which is required a complete understanding of speciation. Our results may be relevant to understanding the original species in other animals, including humans.