Spatio-temporal dependency of radiotherapy induced cardiac toxicity in a novel preclinical model

新型临床前模型中放疗引起的心脏毒性的时空依赖性

• 批准号: MR/V009605/1
• 负责人: Karl Butterworth
• 金额: $ 93.72万
• 依托单位: Queen's University Belfast
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FV009605%2F1
• 关键词: Spatio; temporal; dependency; radiotherapy; induced

Radiotherapy is an excellent treatment for many types of cancer and about half of all patients can be cured by its use. Despite its success, radiotherapy can result in harmful side effects which can have severe consequences on the quality of life and survival of patients following treatment. In particular, patients who receive chest radiotherapy for different cancers may develop unwanted side effects in the heart which can be life threatening. In this project, we will investigate different strategies that may be capable of minimizing the effects of radiotherapy by optimising radiotherapy is delivered. This will focus on avoiding structures in the heart that are very sensitive to radiation and will use a new technique to deliver radiotherapy at very high dose rates called FLASH-RT. We will use this information to design better ways of delivering radiotherapy that will reduce harmful effects in the heart, allowing even higher doses of radiotherapy to delivered which could improve outcomes for patients.

放射治疗是治疗多种癌症的绝佳方法，大约一半的患者可以通过放射治疗治愈。尽管放射治疗取得了成功，但它也会导致有害的副作用，这些副作用可能会对治疗后患者的生活质量和生存造成严重后果。特别是，接受不同癌症胸部放射治疗的患者可能会在心脏产生不想要的副作用，这可能危及生命。在这个项目中，我们将研究不同的策略，通过优化放射治疗的交付，可能能够将放射治疗的影响降至最低。这将侧重于避免心脏中对辐射非常敏感的结构，并将使用一种名为闪光放射治疗的新技术以非常高的剂量率进行放射治疗。我们将利用这些信息来设计更好的放射治疗方法，以减少对心脏的有害影响，允许进行更高剂量的放射治疗，从而改善患者的预后。

项目成果

Assessment of Variabilities in Lung-Contouring Methods on CBCT Preclinical Radiomics Outputs.

评估CBCT临床前放射线型输出中含有肺部肺部方法的变异性。

• DOI: 10.3390/cancers15102677
• 发表时间: 2023-05-09
• 期刊: Cancers
• 影响因子: 5.2

A scoping review of small animal image-guided radiotherapy research: Advances, impact and future opportunities in translational radiobiology.

• DOI: 10.1016/j.ctro.2022.04.004
• 发表时间: 2022-05
• 期刊: Clinical and translational radiation oncology
• 影响因子: 3.1

Murine models of radiation cardiotoxicity: a systematic review and recommendations for future studies.

• DOI: 10.1016/j.radonc.2022.04.030
• 发表时间: 2022-05
• 期刊: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
• 作者: G. Walls;Reagan O'Kane;M. Ghita;R. Kuburas;C. McGarry;A. Cole;S. Jain;K. Butterworth

Spatial Gene Expression Changes in the Mouse Heart After Base-Targeted Irradiation.

碱基靶向照射后小鼠心脏的空间基因表达变化。

• DOI: 10.1016/j.ijrobp.2022.08.031
• 发表时间: 2023
• 期刊: International journal of radiation oncology, biology, physics
• 作者: Walls GM