Urgent research and surveillance on Covid-19 using the new OpenSAFELY secure platform across 55 million patients' full linked primary care records

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We are delivering a platform for analysing healthcare data, currently including 27 million patients' GP records (with identifiable information removed), soon expanding to 55 million. This unprecedented scale is needed for rapid results during Covid-19.OpenSAFELY uses a new model for maximum efficiency and privacy: rather than copying large volumes of information from GP records into another location, which involves security risks, we have instead built a secure analytics platform inside the data centres where GP records already reside, and linked to all relevant Covid-19 outcomes data such as death records and intensive care.We have set this up rapidly and our first analyses are already complete. We now urgently need funds to sustain the platform, and to accelerate and expand our work on the following three workstreams:1) Further research to identify which patients are at higher risk of admission, ventilation and death from Covid-19, to inform management, seclusion advice, service planning, and underlying mechanisms behind these findings (e.g. is there higher risk among BAME groups simply because of previous medical conditions?); and to explore hypotheses on certain drugs helping to protect people against poor outcomes, including ibuprofen, asthma drugs, anticoagulants, and other treatments. 2) Predicting local spread and service need, and evaluating exit strategies from lockdown, by creating models of disease transmission which combine "disease-dynamics" approaches with detailed clinical data on Covid-19 prevalence and the population at risk in every local area.3) Measuring and mitigating the indirect health impacts of Covid-19 on, for example, cancer diagnosis and referrals, cardiovascular management, vaccinations, etc, and identifying urgent necessary actions both nationally and in smaller regions.