Rapid Research for Xylazine Response

赛拉嗪反应的快速研究

基本信息

批准号：
10836135
负责人：
DANIELLE GERMAN
金额：
$ 32.75万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-15 至 2025-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10836135
关键词：
Abscess Affect Animals Awareness Baltimore Behavioral Belief Cessation of life Characteristics Collaborations Communities Country Data Dedications Development Discrimination Drug usage Drug user Enrollment Ensure Epidemiology Fentanyl Geographic Locations Geography Goals Government Agencies HIV HIV Infections Harm Reduction Health Health Services Accessibility Healthcare Healthcare Systems Heroin Illicit Drugs Injecting drug user Injections Intervention Interview Knowledge Location Maryland Medical Examiners Methods Mid-Atlantic Region Naloxone Necrosis Opioid Outcome Overdose Persons Pharmaceutical Preparations Prevalence Prevention strategy Provider Public Health Puerto Rico Qualitative Methods Recording of previous events Reporting Research Respondent Risk Risk Factors Sampling Services Site Skin Tissue Soft Tissue Infections Surveys Time Translating Wound Infection Xylazine cohort drug testing epidemiology study experience improved medical attention mortality non-opioid analgesic opioid overdose overdose death overdose risk peer prevent recruit response sedative service providers social stigma stem surveillance study treatment program wound wound care

项目摘要

Project Summary Xylazine is an emerging serious threat to people who inject drugs (PWID). Xylazine and fentanyl drug mixtures elevate risk overdose and because xylazine is not an opioid, naloxone does not reverse its effects. Despite the increasing presence of xylazine in overdose deaths across the US, there is limited epidemiologic research focused on characterizing the prevalence and risk factors of its use in settings where mortality data indicates a known elevated risk. Although there has been a marked uptick of severe wounds and necrosis among those using drugs that contain xylazine, the specific drug use practices or other characteristics related to the development of wounds are not known. The goal of this research is to generate urgently needed evidence to understand the prevalence, risk factors, knowledge, and harm reduction practices associated with xylazine use and the development of wounds among PWID, in order to effectively inform practice and raise awareness among the affected communities, health care and harm reduction service providers and the public regarding the health risks associated with xylazine. We propose a mixed methods approach using respondent-driven sampling to identify and survey approximately n=300 PWID in Baltimore and n=40 qualitative interviews with those who use xylazine, health care and harm reduction providers. We will estimate the prevalence and correlates of both intentional and suspected xylazine use and examine xylazine-specific overdose knowledge, beliefs and practices. We will determine the prevalence of wounds associated with xylazine use and the association between HIV infection, drug use practices and wounds. We will also characterize barriers to accessing wound care using qualitative methods. This research on a sudden emerging illicit drug will generate time-sensitive knowledge that will directly contribute to preventing the harmful consequences associated with xylazine emergence. We will translate our findings and conduct broad dissemination, working with local stakeholders, partner organizations, and governmental agencies to inform overdose and treatment programs.

项目摘要撒嗪是对注射毒品（PWID）的人们的重大威胁。木嗪和芬太尼药物混合物升高的风险过量，并且由于甲基嗪不是阿片类药物，因此纳洛酮不会扭转其作用。尽管有在整个美国的过量死亡中，木嗪的存在越来越多，流行病学研究有限专注于表征其在死亡率数据表明A的情况下使用的患病率和风险因素已知的风险升高。尽管在这些人中有明显的严重伤口和坏死使用含有甲基嗪的药物，特定的药物使用实践或与该药物相关的其他特征伤口的发育尚不清楚。这项研究的目的是生成急需的证据了解与使用木嗪相关的流行，风险因素，知识和减少危害的实践以及PWID之间伤口的发展，以有效地为实践提供信息并提高认识在受影响的社区中，医疗保健和减少危害服务提供者和公众关于与木嗪有关的健康风险。我们提出了一种使用受访者驱动的混合方法方法在巴尔的摩识别和调查大约n = 300个PWID，n = 40个定性访谈那些使用木马，医疗保健和减少危害的人。我们将估计患病率和有意和可疑使用的相关性并检查甲基嗪特异性过量知识，信念和实践。我们将确定与二甲嗪使用相关的伤口的患病率和艾滋病毒感染，药物使用实践和伤口之间的关联。我们还将描述使用定性方法获得伤口护理。这项关于突然出现的非法药物的研究将产生时间敏感的知识将直接有助于防止与之相关的有害后果撒嗪的出现。我们将翻译我们的发现并进行广泛的传播，与当地合作利益相关者，合作伙伴组织和政府机构为过量用药和治疗计划提供信息。