An analytical framework for Test, Trace and Isolate in the UK: optimising and targeting deployment alongside other measures.

英国的测试、追踪和隔离分析框架：与其他措施一起优化和定位部署。

• 批准号: MR/V028618/1
• 负责人: Elizabeth Fearon
• 金额: $ 53.01万
• 依托单位: London School of Hygiene & Tropical Medicine
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FV028618%2F1
• 关键词: analytical; framework; Test; Trace; Isolate

We will develop a robust analytical framework to guide decisions about the deployment of Test, Trace and Isolate (TTI) to control the SARS CoV2 epidemic over the next 12 months. As the UK eases lockdown and workplaces, leisure venues and schools re-open, refining and targeting TTI is necessary to prevent the return of rapid exponential epidemic growth. This will require quick feedback, assessment and integration with real-time epidemiological, behavioural and operational data. We will develop mathematical models of SARS CoV2 transmission and TTI processes, to assess how TTI could be most effectively refined and targeted in association with other control measures, and to develop metrics to assess TTI performance. We will consider how both the design of the TTI system and environmental factors affect people's behaviour. We will respond to emerging questions but currently prioritise: 1) optimal combinations of TTI, screening and physical distancing measures, both to reduce transmission and to protect vulnerable groups; 2) appraisal of the role of behavioural responses to take up and adhere to TTI policies, including trade-offs and the consequences for how policies are supported; 3) signals to initiate stepped up intervention intensity; 4) assessment of our understanding of transmission patterns.

我们将制定一个强有力的分析框架，指导有关在未来12个月内部署检测、追踪和隔离（TTI）以控制SARS CoV2流行的决策。随着英国放松封锁，工作场所、休闲场所和学校重新开放，有必要改善和针对TTI，以防止疫情再次呈指数级快速增长。这将需要快速反馈、评估和整合实时流行病学、行为和业务数据。我们将建立SARS CoV2传播和TTI过程的数学模型，以评估如何结合其他控制措施最有效地改进和针对性TTI，并制定评估TTI绩效的指标。我们会考虑交通运输系统的设计和环境因素如何影响人们的行为。我们将对新出现的问题作出回应，但目前的重点是：1)TTI、筛查和保持身体距离措施的最佳组合，以减少传播并保护弱势群体；2)评估行为反应在接受和遵守交通运输运输政策方面的作用，包括权衡和如何支持政策的后果；3)启动干预力度加大的信号；4)评估我们对传播模式的理解。

项目成果

Contact tracing is an imperfect tool for controlling COVID-19 transmission and relies on population adherence.

• DOI: 10.1038/s41467-021-25531-5
• 发表时间: 2021-09-13
• 期刊: Nature communications
• 影响因子: 16.6
• 作者: Davis EL;Lucas TCD;Borlase A;Pollington TM;Abbott S;Ayabina D;Crellen T;Hellewell J;Pi L;CMMID COVID-19 Working Group;Medley GF;Hollingsworth TD;Klepac P
• 通讯作者: Klepac P

The SARS-CoV-2 pandemic: remaining uncertainties in our understanding of the epidemiology and transmission dynamics of the virus, and challenges to be overcome.

• DOI: 10.1098/rsfs.2021.0008
• 发表时间: 2021-12-06
• 期刊: Interface focus
• 影响因子: 4.4
• 作者: Anderson RM;Vegvari C;Hollingsworth TD;Pi L;Maddren R;Ng CW;Baggaley RF
• 通讯作者: Baggaley RF

Pooling sputum for Xpert MTB/RIF and Xpert Ultra testing during the Covid-19 pandemic in Lao People's Democratic Republic.

• DOI: 10.1371/journal.pgph.0000116
• 发表时间: 2022
• 期刊: PLOS global public health

On the use of LFA tests in contact tracing: preliminary findings

关于 LFA 测试在接触者追踪中的使用：初步结果

• 发表时间: 2021
• 作者: Fearon E

Comparison of quarantine and testing strategies to prevent onwards infection from infected travellers returning to the UK from abroad

比较隔离和检测策略，以防止从国外返回英国的受感染旅行者继续感染

• 发表时间: 2021
• 作者: Fearon E