Development of novel anti-cancer agents based on cytochrome P450-mediated epoxides of omega-3 fatty acids

基于细胞色素 P450 介导的 omega-3 脂肪酸环氧化物开发新型抗癌药物

• 批准号: nhmrc : 1087248
• 负责人: A/Pr Colin Dunstan
• 金额: $ 63.31万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/development-novel-anti-fatty-acids/519168
• 关键词: Development; novel; anti; cancer; agents

There are few effective treatments for advanced breast cancer. Dietary ?-3 and ?-6 fatty acids respectively decrease and increase the risk of cancer spread. We have found that ?-3 fatty acid epoxide metabolites inhibit the growth of tumour cells and have prepared analogues that are highly active in vivo in animal models of breast cancer. This project will improve and optimise these agents that hold promise as a new class of anti-cancer drugs with the potential to treat advanced disease.

对于晚期乳腺癌，几乎没有有效的治疗方法。节食？- 3、？6种脂肪酸分别降低和增加癌症扩散的风险。我们找到了？- 3脂肪酸环氧化物代谢物抑制肿瘤细胞的生长，并制备了在乳腺癌动物模型体内具有高度活性的类似物。该项目将改进和优化这些药物，这些药物有望成为一类新的抗癌药物，具有治疗晚期疾病的潜力。