Pharmacological development of a stable cytochrome P450-mediated omega-3 fatty acid epoxide analogue as a novel anti-metastatic agent

稳定细胞色素 P450 介导的 omega-3 脂肪酸环氧化物类似物作为新型抗转移剂的药理学开发

• 批准号: nhmrc : 1145424
• 负责人: A/Pr Colin Dunstan
• 金额: $ 40.56万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/pharmacological-development-stable-metastatic-agent/1320451
• 关键词: Pharmacological; development; stable; cytochrome; P450

Dietary ?-3 fatty acids decrease the risk of cancer metastasis. We have found that a certain ?-3 fatty acid metabolite inhibits tumour cell migration but is too unstable to be a useful drug. We have now prepared a stable version of this metabolite for in vivo use as a potential anti-metastatic drug. In this project we will define the mechanism of action of this novel agent and evaluate how it may be best used in patient treatments by testing in a range of in vivo animal models of metastasis.

饮食？-3脂肪酸可降低癌症转移的风险。我们发现，一种特定的？-3脂肪酸代谢产物可以抑制肿瘤细胞的迁移，但它太不稳定，不能作为一种有用的药物。我们现在已经制备了这种代谢物的稳定版本，用于体内作为潜在的抗转移药物。在这个项目中，我们将定义这种新型药物的作用机制，并通过在一系列体内转移动物模型中的测试来评估它如何最好地用于患者的治疗。