Pharmacological development of a stable cytochrome P450-mediated omega-3 fatty acid epoxide analogue as a novel anti-metastatic agent

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Dietary ω-3 fatty acids decrease the risk of cancer metastasis. We have found that a certain ω-3 fatty acid metabolite inhibits tumour cell migration but is too unstable to be a useful drug. We have now prepared a stable version of this metabolite for in vivo use as a potential anti-metastatic drug. In this project we will define the mechanism of action of this novel agent and evaluate how it may be best used in patient treatments by testing in a range of in vivo animal models of metastasis.