Osteoblast Control of Mesenchymal Progenitor Cell Differentiation: The Role of Glucocorticoids and Wnt Signalling.

成骨细胞对间充质祖细胞分化的控制：糖皮质激素和 Wnt 信号传导的作用。

• 批准号: nhmrc : 570946
• 负责人: A/Pr Colin Dunstan
• 金额: $ 29.55万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/osteoblast-control-mesenchymal-wnt-signalling/99112
• 关键词: Osteoblast; Control; Mesenchymal; Progenitor; Cell

Osteoporosis is an important and growing health issue. Reduced ability to make new bone is an important cause of osteoporosis. In this project we will study how the immature cells which eventually make bone are recruited and controlled. In particular, we will study how genes coding for important growth factors are regulated so that the proper signals are sent to young cells to induce them to become bone-making rather than fat-making cells.

骨质疏松症是一个重要的和日益增长的健康问题。骨质疏松症的一个重要原因是骨质疏松症的形成。在这个项目中，我们将研究如何招募和控制最终形成骨骼的未成熟细胞。特别是，我们将研究编码重要生长因子的基因是如何被调节的，以便将适当的信号发送到年轻细胞，诱导它们成为造骨细胞而不是造脂细胞。