SOLUTION STRUCTURES DETERMINATION OF TRAF2LE: CANCER
SOLUTION STRUCTURES DETERMINATION OF TRAF2LE: CANCER
批准号:
6118315
负责人:
Milton H. Werner
金额:
$0.17万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1998
资助国家:
美国
项目状态:
已结题
起止时间:
1998-12-10 至 1999-11-30
中文摘要
上述蛋白质接收来自肿瘤亚群的信号
含有死亡结构域的坏死因子受体(TNFR)。一个
第二类TNFR与TRAF分子相互作用,传递
导致细胞增殖而不是细胞死亡的信号。质量
对TRAF2进行了光谱和蛋白质印迹分析,以
定义最小交互作用域,以定义交互
CD30和CD40的表面,为全面结构分析做准备
TRAF/受体结构域复合体。
英文摘要
The aforementioned proteins receive signals from a subset of tumor
necrosis factor receptors (TNFRs) that contain a death domain. A
second class of TNFRs interact with the TRAF molecules to transmit a
signal that leads to cell proliferation instead of cell death. Mass
spectrometry and Western blot analysis have been applied to TRAF2 to
define the minimal interacting domain, to define the interaction
surface of CD30 and CD40 in preparation for a full structural analysis
of a TRAF/receptor domain complex.
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