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SYMPATHETIC FUNCTION IN ELDERLY HUMAN HYPERTENSION

SYMPATHETIC FUNCTION IN ELDERLY HUMAN HYPERTENSION
老年人高血压的交感功能
批准号:
6297119
负责人:
Mark A Supiano
金额:
$0.02万
依托单位国家:
美国
项目类别:
财政年份:
1998
资助国家:
美国
项目状态:
已结题
起止时间:
1998-12-01 至 1999-11-30

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中文摘要
翻译
该建议的总体目标是确定交感神经系统(SNS)功能的年龄相关变化、对胰岛素代谢作用的敏感性以及血压的盐敏感性对老年人高血压的影响程度。我们假设,通常允许适应这些年龄相关变化的代偿机制在老年高血压患者中受损。我们进一步假设,六个月有氧运动训练计划后胰岛素敏感性的改善和血压的降低将与盐敏感性、SNS功能和肾脏血流动力学的改变(特别是钠过滤的减少)有关。
英文摘要
The overall objective of this proposal is to determine the extent to which age-related changes in sympathetic nervous system (SNS) function, sensitivity to the metabolic effects of insulin, and salt-sensitivity of blood pressure contribute to hypertension in the elderly. We hypothesize that the compensatory mechanisms which normally allow adaptation to these age-related changes are impaired in older hypertensives. We further hypothesize that an improvement insulin sensitivity and decrease in blood pressure following a six month aerobic exercise training program will be associated with alterations in salt sensitivity, SNS function and renal hemodynamics (specifically a decrease in filtration for sodium).
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Cardiovasomobility Research Training Program
  • 批准号:
    10439465
  • 项目类别:
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  • 财政年份:
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  • 财政年份:
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  • 财政年份:
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  • 财政年份:
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海外基金