NEUROHUMORAL MECHANISMS IN GERIATRIC HYPERTENSION: ROLE OF ALDOSTERONE

老年高血压的神经体液机制：醛固酮的作用

• 批准号: 7376499
• 负责人: Mark A Supiano
• 金额: $ 2.45万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-05 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376499
• 关键词: aldosterone; blood pressure; blood vessels; geriatrics; hypertension; role

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to determine if increased levels of a hormone produced in the adrenal gland, aldosterone, plays a part in the increase in blood pressure that is common as people get older. The study is designed to test for interactions between aldosterone and other factors known to be important in high blood pressure in older people. These factors are stiffness of blood vessels, the activity of the sympathetic nervous system (the part of the nervous system that produces the chemical norepinephrine that controls heart rate and blood pressure), insulin, and a relaxing factor produced by blood vessels (nitric oxide). These systems will be tested at the beginning of the study, and again six months later following treatment with one of two medications that are used to treat hypertension. Men and women aged 60 to 80 years will be recruited. To begin the study, systolic blood pressure must be less than 180 (top number) and diastolic blood pressure must be less than 110 (bottom number). Subjects in this study will be randomly assigned (similar to using a coin flip) to take either spironolactone (this medication blocks the effects of aldosterone) or hydrochlorothizide (a diuretic or water pill). This study is important because it will provide new information about the actions of aldosterone that may lead to increased blood pressure in older people, and the potential benefits of treating high blood pressure using an aldosterone blocking medication.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。这项研究的目的是确定肾上腺中产生的一种激素--醛固酮水平的增加是否在人们变老时常见的血压升高中起作用。这项研究旨在测试醛固酮和其他已知在老年人高血压中重要的因素之间的相互作用。这些因素是血管的硬度，交感神经系统的活动（神经系统的一部分，产生控制心率和血压的化学去甲肾上腺素），胰岛素和血管产生的放松因子（一氧化氮）。这些系统将在研究开始时进行测试，并在六个月后再次使用两种用于治疗高血压的药物之一进行治疗。将招募60至80岁的男性和女性。为了开始研究，收缩压必须低于180（最高数字），舒张压必须低于110（最低数字）。本研究中的受试者将被随机分配（类似于使用抛硬币）服用螺内酯（这种药物阻断醛固酮的作用）或氢氯噻嗪（利尿剂或水丸）。这项研究很重要，因为它将提供有关醛固酮可能导致老年人血压升高的作用的新信息，以及使用醛固酮阻断药物治疗高血压的潜在益处。