Cardiovasomobility Research Training Program

心血管运动研究培训计划

• 批准号: 10439465
• 负责人: Mark A Supiano
• 金额: $ 24.27万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10439465
• 关键词: Research Training; Training Programs

Project Summary/Abstract This is a new T32 application to establish an innovative, interdisciplinary training program aimed at integrating mobility and cardiovascular health research at the University of Utah. Mobility and cardiovascular health are inextricably linked and hence the Cardiovasomobility Research Training Program (CRTP) will provide research training at the interface of these two important determinants of health and add to our understanding of their interactions. CRTP will be a comprehensive, interdisciplinary, bench-to-bedside training program building upon existing strengths at the University of Utah in the fields of physical function and cardiovascular medicine. The 28 participating faculty mentors selected for this training program are accomplished investigators with established research funding and mentoring experience. Faculty hail from the Departments of Internal Medicine, Radiology, Nutrition and Integrative Physiology, Physical Therapy, Mechanical and Bio-Engineering, and the Molecular Medicine Program; and represent many disciplines including exercise physiology, geriatric medicine, cardiology, molecular biology, metabolism, imaging, and physical therapy. Thus, the CRTP will span the translational spectrum of cardiovascular health and mobility research that will provide a unique opportunity for the program’s trainees to both parse out and integrate these important determinants of health. The CRTP has four Specific Aims: 1) To provide administrative structure and oversight for research training in cardiovasomobility; 2) To provide trainee-specific career development that includes comprehensive training and mentorship in the integration of mobility and cardiovascular health research; 3) To evaluate programmatic outcomes; and 4) To recruit and support a diverse group of trainees with respect to gender and racial composition. The program requests support for 2 Pre-Doctoral and 3 Post-Doctoral (MD or PhD) trainee positions. Pre-Doctoral trainees will be recruited from the graduate programs in Nutrition and Integrative Physiology, Rehabilitation Science, MD/PhD, and Bioscience PhD Programs. MD Post-Doctoral trainees will be drawn largely from the clinical fellowship programs and PhD Post-Doctoral trainees will be recruited from individuals applying to join the research programs of participating faculty mentors. The training program will be led by two very experienced investigators – an exercise physiologist and a geriatrician – to ensure comprehensive and appropriate support of the program’s physician and non-physician trainees. They will be supported by an outstanding group of committed and experienced colleagues who will serve as the program’s Executive Committee. An External Advisory Committee will be formed to provide additional programmatic review. The University of Utah is poised to respond to the need to train the next generation of research investigators in the integration of mobility and cardiovascular health by offering this comprehensive, interdisciplinary CRTP.

项目总结/文摘

项目成果

Preserved endothelium-independent vascular function with aging in men and women: evidence from the peripheral and cerebral vasculature.

随着男性和女性衰老，保留内皮依赖性血管功能：来自外周和脑血管系统的证据。

• DOI: 10.1152/japplphysiol.00571.2022
• 发表时间: 2023
• 期刊: Journal of applied physiology (Bethesda, Md. : 1985)
• 作者: Shields,KatherineL;Jarrett,CatherineL;Bisconti,AngelaV;Park,SoungHun;Craig,JesseC;Broxterman,RyanM;Richardson,RussellS
• 通讯作者: Richardson,RussellS

Chronic antioxidant administration restores macrovascular function in patients with heart failure with reduced ejection fraction.

• DOI: 10.1113/ep088686
• 发表时间: 2020-08
• 期刊: Experimental physiology
• 影响因子: 2.7
• 作者: Bunsawat K;Ratchford SM;Alpenglow JK;Park SH;Jarrett CL;Stehlik J;Drakos SG;Richardson RS;Wray DW
• 通讯作者: Wray DW

Acute high-intensity exercise and skeletal muscle mitochondrial respiratory function: role of metabolic perturbation.

急性高强度运动和骨骼肌线粒体呼吸功能：代谢扰动的作用。

• DOI: 10.1152/ajpregu.00158.2021
• 发表时间: 2021
• 期刊: American journal of physiology. Regulatory, integrative and comparative physiology
• 作者: Lewis,MatthewT;Blain,GregoryM;Hart,CoreyR;Layec,Gwenael;Rossman,MatthewJ;Park,Song-Young;Trinity,JoelD;Gifford,JaysonR;Sidhu,SimranjitK;Weavil,JoshuaC;Hureau,ThomasJ;Jessop,JacobE;Bledsoe,AmberD;Amann,Markus;Richards
• 通讯作者: Richards

Salty skin: Where excess sodium goes for a rendezvous.

• DOI: 10.1113/jp283274
• 发表时间: 2022-07
• 期刊: JOURNAL OF PHYSIOLOGY-LONDON
• 影响因子: 5.5
• 作者: Linder, Braxton A.;Mehrer, Justin D.;Bunsawat, Kanokwan
• 通讯作者: Bunsawat, Kanokwan

A NIRS-derived Skeletal Muscle Oxygen Consumption Method Accurately Reflects the Gold Standard Direct Fick Method during Single-leg Knee Extension Exercise.

NIRS 衍生的骨骼肌耗氧量方法准确反映了单腿膝关节伸展运动中的黄金标准直接菲克法。

• 发表时间: 2022
• 期刊: FASEB journal : official publication of the Federation of American Societies for Experimental Biology
• 作者: Craig,JesseC;Broxterman,RyanM;Barret-O'Keefe,Zachary;Wray,DWalter;Barstow,ThomasJ;Richardson,RussellS;Trinity,JoelD
• 通讯作者: Trinity,JoelD