Cardiovasomobility Research Training Program

心血管运动研究培训计划

• 批准号: 10439465
• 负责人: Mark A Supiano
• 金额: $ 24.27万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10439465
• 关键词: Research Training; Training Programs

Project Summary/Abstract This is a new T32 application to establish an innovative, interdisciplinary training program aimed at integrating mobility and cardiovascular health research at the University of Utah. Mobility and cardiovascular health are inextricably linked and hence the Cardiovasomobility Research Training Program (CRTP) will provide research training at the interface of these two important determinants of health and add to our understanding of their interactions. CRTP will be a comprehensive, interdisciplinary, bench-to-bedside training program building upon existing strengths at the University of Utah in the fields of physical function and cardiovascular medicine. The 28 participating faculty mentors selected for this training program are accomplished investigators with established research funding and mentoring experience. Faculty hail from the Departments of Internal Medicine, Radiology, Nutrition and Integrative Physiology, Physical Therapy, Mechanical and Bio-Engineering, and the Molecular Medicine Program; and represent many disciplines including exercise physiology, geriatric medicine, cardiology, molecular biology, metabolism, imaging, and physical therapy. Thus, the CRTP will span the translational spectrum of cardiovascular health and mobility research that will provide a unique opportunity for the program’s trainees to both parse out and integrate these important determinants of health. The CRTP has four Specific Aims: 1) To provide administrative structure and oversight for research training in cardiovasomobility; 2) To provide trainee-specific career development that includes comprehensive training and mentorship in the integration of mobility and cardiovascular health research; 3) To evaluate programmatic outcomes; and 4) To recruit and support a diverse group of trainees with respect to gender and racial composition. The program requests support for 2 Pre-Doctoral and 3 Post-Doctoral (MD or PhD) trainee positions. Pre-Doctoral trainees will be recruited from the graduate programs in Nutrition and Integrative Physiology, Rehabilitation Science, MD/PhD, and Bioscience PhD Programs. MD Post-Doctoral trainees will be drawn largely from the clinical fellowship programs and PhD Post-Doctoral trainees will be recruited from individuals applying to join the research programs of participating faculty mentors. The training program will be led by two very experienced investigators – an exercise physiologist and a geriatrician – to ensure comprehensive and appropriate support of the program’s physician and non-physician trainees. They will be supported by an outstanding group of committed and experienced colleagues who will serve as the program’s Executive Committee. An External Advisory Committee will be formed to provide additional programmatic review. The University of Utah is poised to respond to the need to train the next generation of research investigators in the integration of mobility and cardiovascular health by offering this comprehensive, interdisciplinary CRTP.

项目摘要/摘要 这是一个新的T32应用程序，旨在建立一个创新的跨学科培训计划，旨在 犹他大学的机动性和心血管健康研究。机动性和心血管健康 千丝万缕的联系，因此心血管运动研究培训计划(CRTP)将提供研究 在这两个重要的健康决定因素之间进行培训，并增加我们对它们的理解 互动。CRTP将是一个全面的、跨学科的、从板凳到床边的培训计划，建立在 犹他大学在身体机能和心血管医学领域的现有优势。这个 为该培训计划挑选的28名参与教师导师是具有丰富经验的调查人员 建立了研究经费和指导经验。来自内务部的教职员工 医学、放射学、营养学与综合生理学、物理疗法、机械与生物工程、 和分子医学计划；并代表许多学科，包括运动生理学、老年病学 医学、心脏病学、分子生物学、新陈代谢、成像和物理治疗。因此，CRTP将跨越 心血管健康和机动性研究的翻译谱将提供一个独特的机会 对于该计划的受训人员来说，既要分析出这些重要的健康决定因素，又要把它们结合起来。 CRTP有四个具体目标：1)为#年的研究培训提供行政结构和监督 心血管疾病；2)提供针对受训人员的职业发展，包括全面培训 以及在移动性和心血管健康研究的整合方面的指导；3)评估方案 结果；以及4)在性别和种族方面招募和支持不同的受训人员群体 组成。该计划要求为2名博士后和3名博士后(医学博士或博士)实习生提供支持 各就各位。博士前实习生将从营养学和综合医学研究生项目中招聘 生理学、康复科学、医学博士和生物科学博士课程。MD博士后实习生将 将主要从临床奖学金计划中提取，博士后实习生将从 申请加入参与教师导师的研究项目的个人。培训计划将是 由两名非常有经验的研究人员领导--一名运动生理学家和一名老年医生--以确保 全面和适当地支持该计划的医生和非医生学员。他们将会是 由一群忠诚而有经验的优秀同事提供支持，他们将担任该计划的 执行委员会。将成立一个外部咨询委员会，以提供额外的方案 复习一下。犹他大学准备对培养下一代研究人员的需求做出回应 通过提供这一全面的、 跨学科CRTP。

项目成果

Chronic antioxidant administration restores macrovascular function in patients with heart failure with reduced ejection fraction.

• DOI: 10.1113/ep088686
• 发表时间: 2020-08
• 期刊: Experimental physiology
• 影响因子: 2.7
• 作者: Bunsawat K;Ratchford SM;Alpenglow JK;Park SH;Jarrett CL;Stehlik J;Drakos SG;Richardson RS;Wray DW
• 通讯作者: Wray DW

Preserved endothelium-independent vascular function with aging in men and women: evidence from the peripheral and cerebral vasculature.

随着男性和女性衰老，保留内皮依赖性血管功能：来自外周和脑血管系统的证据。

• DOI: 10.1152/japplphysiol.00571.2022
• 发表时间: 2023
• 期刊: Journal of applied physiology (Bethesda, Md. : 1985)
• 作者: Shields,KatherineL;Jarrett,CatherineL;Bisconti,AngelaV;Park,SoungHun;Craig,JesseC;Broxterman,RyanM;Richardson,RussellS
• 通讯作者: Richardson,RussellS

Acute high-intensity exercise and skeletal muscle mitochondrial respiratory function: role of metabolic perturbation.

急性高强度运动和骨骼肌线粒体呼吸功能：代谢扰动的作用。

• DOI: 10.1152/ajpregu.00158.2021
• 发表时间: 2021
• 期刊: American journal of physiology. Regulatory, integrative and comparative physiology
• 作者: Lewis,MatthewT;Blain,GregoryM;Hart,CoreyR;Layec,Gwenael;Rossman,MatthewJ;Park,Song-Young;Trinity,JoelD;Gifford,JaysonR;Sidhu,SimranjitK;Weavil,JoshuaC;Hureau,ThomasJ;Jessop,JacobE;Bledsoe,AmberD;Amann,Markus;Richards
• 通讯作者: Richards

Salty skin: Where excess sodium goes for a rendezvous.

• DOI: 10.1113/jp283274
• 发表时间: 2022-07
• 期刊: JOURNAL OF PHYSIOLOGY-LONDON
• 影响因子: 5.5
• 作者: Linder, Braxton A.;Mehrer, Justin D.;Bunsawat, Kanokwan
• 通讯作者: Bunsawat, Kanokwan

A NIRS-derived Skeletal Muscle Oxygen Consumption Method Accurately Reflects the Gold Standard Direct Fick Method during Single-leg Knee Extension Exercise.

NIRS 衍生的骨骼肌耗氧量方法准确反映了单腿膝关节伸展运动中的黄金标准直接菲克法。

• 发表时间: 2022
• 期刊: FASEB journal : official publication of the Federation of American Societies for Experimental Biology
• 作者: Craig,JesseC;Broxterman,RyanM;Barret-O'Keefe,Zachary;Wray,DWalter;Barstow,ThomasJ;Richardson,RussellS;Trinity,JoelD
• 通讯作者: Trinity,JoelD