PHARMACOKINETICS OF CEFTAZIDIME IN CONTINUOUS AMBULATORY PERITONEAL DIALYSIS

头孢他啶在连续不卧床腹膜透析中的药代动力学

• 批准号: 6113507
• 负责人: NANCY A MASON
• 金额: $ 2.14万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6113507
• 关键词: clinical research; continuous ambulatory peritoneal dialysis; dosage; human subject; human therapy evaluation; kidney disorder chemotherapy; lactams; pharmacokinetics; renal failure; serology /serodiagnosis

This is a pilot study to examine the pharmacokinetics of ceftazidime in healthy volunteers with renal dysfunction requiring continuous ambulatory peritoneal dialysis (CAPD) following a single 2 gram dose administered intraperitoneally. The serum and dialysate concentration profiles over the 48 hours study period will be determined.

这是一项初步研究，以检查头孢他啶的药代动力学， 需要持续治疗的肾功能不全的健康志愿者 单次2 g剂量后的非卧床腹膜透析（CAPD） 腹膜内给药。 血清和透析液浓度 将确定48小时研究期间的曲线。