PHARMACOKINETICS OF INTRAPERITONEAL CEFTAZIDIME IN PERITONEAL DIALYSIS

腹膜透析腹腔内注射头孢他啶的药代动力学

• 批准号: 5217635
• 负责人: NANCY A MASON
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5217635
• 关键词: beta lactam antibiotic; clinical research; clinical trials; continuous ambulatory peritoneal dialysis; human subject; kidney disorder; pharmacokinetics

This is a pilot study to examine the pharmacokinetics of ceftazidime in healthy volunteers with renal dysfunction requiring continuous ambulatory peritoneal dialysis following a single 2 gm dose administered intraperitoneally. The serum and dialysate concentration profiles over the 48 hour study period will be determined.

这是一项初步研究，以检查头孢他啶的药代动力学， 需要连续非卧床的肾功能不全的健康志愿者 在单次给予2 gm剂量后进行腹膜透析 腹腔注射 血清和透析液浓度曲线 将确定48小时研究期。