NUTRITIONAL THERAPY OF CHRONIC RENAL FAILURE IN OUTPATIENTS

门诊慢性肾功能衰竭患者的营养治疗

• 批准号: 6114276
• 负责人: MACKENZIE WALSER
• 金额: $ 2.06万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6114276
• 关键词: chronic renal failure; clinical research; diabetic nephropathy; diet therapy; dietary proteins; glomerular filtration rate; hemodialysis; human subject; human therapy evaluation; interstitial nephritis; ketoconazole; kidney disorder chemotherapy; nephrotic syndrome; nutrition related tag; prednisone

Optimal dietary protein intake for adults with the nephrotic syndrome has not yet been established; very-low protein diets are believed to be contraindicated. Nevertheless, 22 adults with the nephrotic syndrome were prescribed a very low protein diet (0.3 g/kg) supplemented with 10-20 g/day of essential amino acids (or, in a few cases, ketoacids) for an average of 10 months. In patients with moderate or severe renal failure, modest improvement was seen (on the average) in proteinuria, serum albumin, and serum cholesterol. In patients with less severe renal failure, three failed to improve, but five showed complete or nearly complete remission of their nephrotic syndrome during the ensuing months, beginning with the start of the diet. Four of them eventually resumed normal diets without recurrence of nephrotic syndrome.

成人肾病综合征患者的最佳膳食蛋白质摄入量 尚未成立；极低蛋白质饮食被认为 禁忌。 尽管如此，22 名患有肾病综合征的成年人 规定了极低蛋白质饮食（0.3 g/kg），并辅以 10-20 克/天的必需氨基酸（或在少数情况下，酮酸） 平均10个月。 对于中度或重度肾病患者 失败，蛋白尿（平均）略有改善， 血清白蛋白和血清胆固醇。 对于病情不太严重的患者 肾功能衰竭，3 例未能改善，但 5 例显示完全或 在随后的治疗期间，他们的肾病综合征几乎完全缓解 几个月，从开始节食开始。 最终他们四个 恢复正常饮食，肾病综合征未复发。