NUTRITIONAL THERAPY OF CHRONIC RENAL FAILURE IN OUTPATIENTS

成人肾病综合征患者的最佳膳食蛋白质摄入量 尚未建立；极低蛋白质饮食被认为是 禁忌。然而，22名患有肾病综合征的成年人 被处方为极低蛋白质饮食(0.3g/kg)，并补充 每天10-20克必需氨基酸(或在少数情况下，酮酸)，用于 平均10个月。在中度或重度肾脏疾病患者中 失败，蛋白尿(平均)略有改善， 血清白蛋白和血清胆固醇。在病情较轻的患者中 肾功能衰竭，3人没有改善，但5人完全或 他们的肾病综合征在随后的治疗中几乎完全缓解 几个月，从开始节食开始。他们中的四个最终 恢复正常饮食，无肾病综合征复发。

Optimal dietary protein intake for adults with the nephrotic syndrome has not yet been established; very-low protein diets are believed to be contraindicated. Nevertheless, 22 adults with the nephrotic syndrome were prescribed a very low protein diet (0.3 g/kg) supplemented with 10-20 g/day of essential amino acids (or, in a few cases, ketoacids) for an average of 10 months. In patients with moderate or severe renal failure, modest improvement was seen (on the average) in proteinuria, serum albumin, and serum cholesterol. In patients with less severe renal failure, three failed to improve, but five showed complete or nearly complete remission of their nephrotic syndrome during the ensuing months, beginning with the start of the diet. Four of them eventually resumed normal diets without recurrence of nephrotic syndrome.