In-Silico Modelling and 3D-printing of Dental Implants with Photo-active and Infection-Resistant Coatings (PERIo-Dent-ItiS)

具有光活性和抗感染涂层的牙种植体的计算机建模和 3D 打印 (PERIo-Dent-ItiS)

• 批准号: MR/W004062/1
• 负责人: Animesh Jha
• 金额: $ 25.98万
• 依托单位: University of Leeds
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FW004062%2F1
• 关键词: Silico; Modelling; 3D; printing; Dental

Peri-implantitis is an infection-related condition around the implant, which occurs because of inflammation arising from the acidic interstitial fluid, produced by the presence of bacteria in the biofilm. The biofilms form on the peripheral surface of implants. The acid slowly resorbs the healthy bones, enervates soft-tissue anchorage, loosens the implant, and causes pain. Loss of mechanical support also aggravates the pain and, therefore, compromises the chewing and mastication which are essential for the easier digestion of food. Although, the success rate of implants is 85-90%, however, 10-15% implants fail during lifetime because of the lack of early diagnosis. The diagnosis of failed implants is poor and only when the pain is felt, the patients are prescribed pain killers, monitored before the surgical intervention removes the implant. Innovative Vision: With increasing 50+-years age group needing more implants, there is an urgent need for improving the implants for better osseointegration for preventing mechanical failure. Our goal is to provide infection resistance against bacteria and to design means for ascertaining early signs of biofilm formation. During secondment at Attenborough Dental (AD) in Nottingham, the secondee will use the 3D-printing and Additive Manufacturing facility for fabricating implants for promoting the formation of a strong hard-soft tissue anchorage, and vascularization which will intrinsically prevent the risk of infection from bacteria. The materials patented (PCT/GB2015/052557) at the University of Leeds will form the basis for developing new generations of infection-resistant and photo-responsive implants for the early signs of detection of infection. Objectives: The four objectives are: O.1) to demonstrate in silico and biomechanical modelling approach for the fabrication of standard implants with infection-resistance and photo-responsive coatings, designed from calcium phosphate with CeSr-oxide (CeSrOx)/chitosan as the antibacterial and Europium-Samarium oxide (EuSMOx) as photo-responsive coating, respectively. O.2) We will adopt the steps in O.1 and demonstrate the fabrication of porous Ti-implants for improved micro-fluidics and osseointegration with infection resistance and photo-responsive features for non-invasive diagnostics. The porosity control for microfluidic properties is essential for infection control, improved vascularization, and strong tissue anchorage.O.3) The UoL-AD team will review in silico and biocompatible modelling for design and fabrication of route analogues using 3D-AM with the porous Ti-alloy structure. Such a new design offers one-step surgery for improved osseointegration, infection resistance (CeSrOx), and methods for monitoring healing by interrogating the photo-active EuSmOx layer. O.4) We will focus on microstructural and physical characterizations, stress analysis, bio-compatibility (toxicity, attachment, proliferation), osteogenesis and angiogenesis, and photo-active response in cellular and simulated oral fluid condition of implant materials which will be essential for future animal studies.Secondee: A full-time secondment will fulfil the goals of each objective. The secondment will develop the digital imaging approach for controlling the porosity and bio-mechanical stress using 3D-printing and additive manufacturing facility at AD. The manufacturing of implants with the standard Ti-alloy powder, CeSrOx and EuSmOx mixed with calcium phosphate will be demonstrated, and the properties of implants will be characterized using the state-of-the-art analytical and modelling facilities at AD and UoL. The results of fabrication and characterization will be used for ascertaining the longevity of implants in the oral environment under acidic condition. The training will also aim towards developing business-relevant skills. Important non-confidential results will be published in the peer-reviewed journal, after securing the patent position.

植入物周围是植入物周围与感染相关的疾病，由于生物膜中存在细菌而产生的酸性间质液引起的炎症。生物膜在植入物的外围表面形成。酸慢慢地与健康的骨骼共振，振奋软组织锚固，松开植入物并引起疼痛。机械支撑的丧失还会加剧疼痛，因此损害了咀嚼和咀嚼，这对于更容易消化食物至关重要。尽管植入物的成功率为85-90％，但是由于缺乏早期诊断，植入物在一生中失败了10-15％。失败植入物的诊断很差，只有在感觉到疼痛时，患者被处方止痛药，在手术干预之前对其进行监测。创新的视觉：随着50岁以上年龄段需要更多的植入物，迫切需要改善植入物以更好地进行骨整合以防止机械故障。我们的目标是提供对细菌的感染性和设计手段，以确定生物膜形成的早期迹象。在诺丁汉的Attenborough Dental（AD）的借调过程中，第二次将使用3D打印和添加剂制造设施来制造植入物来促进强大的硬软组织锚固的形成，并在本质上阻止细菌感染的风险。利兹大学获得专利的材料（PCT/GB2015/052557）将为开发新一代的耐亡感染和照相响应植入物的基础，以便早期发现感染的迹象。目的：四个目标是：O.1）在硅和生物力学建模方法中证明，用于制造具有感染耐药性和光子反应性涂料的标准植入物，该植入物是由磷酸钙（cesr-氧化钙（cesrox）/壳聚糖/壳聚糖设计为抗细菌和欧洲裔氧化物（co）的磷酸盐（cesrox）/壳聚糖（co）的抗氧化物（cesrox）和氧化物（co）。 O.2）我们将采用O.1中的步骤，并演示用于改进微荧光学和骨整合的多孔Ti植物，具有感染性抗性和光响应特征，用于非侵入性诊断。微流体特性的孔隙率控制对于感染控制，改善血管形成和强组织锚固至关重要。3）UOL-AD团队将在硅中进行审查，并使用与多孔Ti-Alloy结构的3D-AM设计和制造途径类似物的生物相容性建模。这样的新设计提供了一步手术，可改善骨整合，感染性（Cesrox）和通过询问光活动的Eusmox层来监测愈合的方法。 o.4）我们将重点介绍微观结构和身体特征，压力分析，生物兼容性（毒性，依恋，增殖），成骨和血管生成和血管生成以及植入物质的植入材料口腔流体状况的光活性反应，这对于未来的动物研究至关重要。借调将开发数字成像方法，用于使用AD的3D打印和增材制造设施来控制孔隙率和生物力学应力。将展示用标准Ti-Aloy粉末，Cesrox和Eusmox与磷酸钙混合的植入物的生产，并将使用AD和UOL的最先进的分析和建模设施来表征植入物的性能。制造和表征的结果将用于确定在酸性条件下口服环境中植入物的寿命。该培训还将旨在发展与业务相关的技能。在确保专利位置后，重要的非机密结果将在同行评审期刊上发表。

项目成果

Physiologically Engineered Bone: Quantifying the Mechanical Properties and Investigating Cellular Response of Novel Porous Composite Scaffolds

生理工程骨：量化新型多孔复合支架的机械性能并研究细胞反应

• 发表时间: 2022
• 作者: Abdulaziz D.

Fabrication and Characterisation of Synthetic Double Layered Bone Scaffold

合成双层骨支架的制备和表征

• 发表时间: 2022
• 作者: Yildizbakan L.

TMS 2022 151st Annual Meeting & Exhibition Supplemental Proceedings

TMS 2022 第 151 届年会

• DOI: 10.1007/978-3-030-92381-5_73
• 发表时间: 2022
• 作者: Yildizbakan L