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SAFETY, TOLERABILITY, AND ANTIRETROVIRAL ACTIVITY OF DMP 266

SAFETY, TOLERABILITY, AND ANTIRETROVIRAL ACTIVITY OF DMP 266
DMP 266 的安全性、耐受性和抗逆转录病毒活性
批准号：
6115459
负责人：
JAMES S KAHN
金额：
$3.1万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6115459
关键词：
AIDS therapy CD4 molecule antiAIDS agent antiviral agents clinical research combination chemotherapy drug resistance drug screening /evaluation genotype human subject human therapy evaluation indinavir outcomes research pharmacokinetics protease inhibitor reverse transcriptase inhibitors virus load

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英文摘要
This is a randomized Phase I/II study of indinavir (protease inhibitor) and DMP266 (non-nucleoside RT inhibitor) in patients with CD4 cells between 100-500 and viral load> 20,000 copies/ML. Treatments will be evaluated by viral load, CD4 cell changes and pharmacokinetics. The objective of the study is to evaluate the safety, tolerability, anti-viral activity of DMP266 alone and in combination with indinavir and to characterize the development of resistance to DMP266 by genotypic change of resistant status.
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