Observational Cohort of HIV-Infected Persons

HIV 感染者观察队列

• 批准号: 6646503
• 负责人: JAMES S KAHN
• 金额: $ 11.45万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-25 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6646503
• 关键词: AIDS; AIDS /HIV diagnosis; AIDS education /prevention; AIDS therapy; HIV infections; antiviral agents; automated medical record system; clinical chemistry; combination chemotherapy; communicable disease transmission; gender difference; health care professional practice; health care service evaluation; health services research tag; human subject; human therapy evaluation; managed care; medical records; outcomes research; pathologic process; patient care management; patient oriented research; racial /ethnic difference; therapy compliance; virus load

James O. Kahn, MD is an Associate Professor of Medicine at the University of California, San Francisco (UCSF), Associate Director of the Positive Health Program (PHP) (formally known as the AIDS Program) at San Francisco General Hospital (SFGH) and Associate Director of the UCSF-Gladstone Institute of Virology and Immunology's Center for AIDS Research (CFAR). Additionally, Dr. Kahn is the former chair of the Committee for Human Research at UCSF. He has completed fellowship training in medical oncology and clinical epidemiology, with an emphasis on research methods. With support from a 3-year Career Development Award from the American Cancer Society, Dr. Kahn attained the experience and skills necessary to become an independent investigator and to build a multidisciplinary research team in patient-oriented research. Dr. Kahn has developed an international reputation as a clinical trialist in patient-oriented HIV/AIDS research, with expertise in the areas of antiretroviral drug development, HIV-1 vaccine development, primary HIV-1 infection and prevention of HIV infection. Dr. Kahn has also been a very active mentor for beginning clinical investigators from diverse backgrounds, including younger physicians on faculty in the PHP, as well as visiting fellows from other countries. All junior faculty supported and mentored by Dr. Kahn are active in patient-oriented research. K-24 support will enable Dr. Kahn to achieve his long-term career goal of establishing a clinical research program that will: (1) integrate a multidisciplinary approach to prevention of HIV-1 infection; (2) conduct exploratory clinical research on the determinants of HIV-1 transmission; (3) include a comprehensive mentoring program for HIV/AIDS clinical investigators; and (4) create a clinical outcomes research agenda that focuses on the clinical effectiveness of HIV care in primary care settings. An initial research focus will be an assessment of the impact of current clinical practice guidelines on the primary medical care of HIV- infected adults, and the long-term virologic, immunologic and clinical outcomes in this population. Data for this prospective, observational cohort will be collected with the use of HIVWatch, a web-based, electronic medical record system developed by Dr. Kahn that contains data on patients who receive their medical care at the Positive Health Practice at SFGH. Dr. Kahn's research program has the enthusiastic support of his deuartment. the leadership of the AIDS Research Institute at UCSF and other nationally recognized clinical researchers.

James O. Kahn博士是加州大学弗朗西斯科分校（UCSF）的医学副教授，弗朗西斯科总医院（SFGH）积极健康计划（PHP）（正式称为艾滋病计划）的副主任，以及UCSF-Gladstone病毒学和免疫学研究所艾滋病研究中心（CFAR）的副主任。此外，卡恩博士是加州大学旧金山分校人类研究委员会的前主席。他完成了医学肿瘤学和临床流行病学的奖学金培训，重点是研究方法。在美国癌症协会为期3年的职业发展奖的支持下，Kahn博士获得了成为独立研究者所需的经验和技能，并在以患者为导向的研究中建立了一个多学科的研究团队。Kahn博士在以患者为导向的艾滋病毒/艾滋病研究方面享有国际声誉，在抗逆转录病毒药物开发、HIV-1疫苗开发、原发性HIV-1感染和预防HIV感染等领域拥有专业知识。卡恩博士也一直是一个非常积极的导师开始临床研究人员从不同的背景，包括在PHP教师的年轻医生，以及来自其他国家的访问学者。由卡恩博士支持和指导的所有初级教师都积极参与以患者为导向的研究。K-24的支持将使Kahn博士能够实现他的长期职业目标，即建立一个临床研究计划，该计划将：（1）整合多学科方法来预防HIV-1感染;（2）对HIV-1传播的决定因素进行探索性临床研究;（3）为HIV/AIDS临床研究人员提供全面的指导计划;以及（4）创建一个临床结果研究议程，重点关注艾滋病毒护理在初级保健环境中的临床有效性。最初的研究重点将是评估目前的临床实践指南对艾滋病毒感染成人的初级医疗保健的影响，以及这一人群的长期病毒学、免疫学和临床结局。该前瞻性观察性队列的数据将使用HIVWatch收集，HIVWatch是Kahn博士开发的基于网络的电子病历系统，包含在SFGH积极健康实践中接受医疗护理的患者数据。卡恩博士的研究计划得到了他的同事们的热情支持。加州大学旧金山分校艾滋病研究所和其他国家认可的临床研究人员的领导。