Observational Cohort of HIV-Infected Persons

James O.Kahn，医学博士，加州大学旧金山分校(UCSF)医学副教授，旧金山总医院(SFGH)阳性健康计划(PHP)(正式名称为AIDS计划)副主任，加州大学旧金山分校格拉德斯通病毒学和免疫学研究所艾滋病研究中心(CFAR)副主任。此外，卡恩博士是加州大学旧金山分校人类研究委员会的前主席。他已经完成了内科肿瘤学和临床流行病学的研究员培训，重点是研究方法。在美国癌症协会颁发的为期3年的职业发展奖的支持下，卡恩博士获得了成为一名独立调查员所需的经验和技能，并在以患者为中心的研究中建立了一个多学科研究团队。卡恩博士在以患者为中心的艾滋病毒/艾滋病研究方面建立了国际声誉，在抗逆转录病毒药物开发、艾滋病毒-1疫苗开发、艾滋病毒-1原发感染和艾滋病毒感染预防领域拥有专业知识。卡恩博士也一直是来自不同背景的初级临床研究人员的非常积极的导师，包括PHP教员中的年轻医生，以及来自其他国家的访问研究员。所有由卡恩博士支持和指导的初级教员都积极参与以患者为导向的研究。K-24支持将使卡恩博士能够实现他建立临床研究计划的长期职业目标，该计划将：(1)整合预防艾滋病毒-1感染的多学科方法；(2)对艾滋病毒-1传播的决定因素进行探索性临床研究；(3)包括针对艾滋病毒/艾滋病临床研究人员的全面指导计划；以及(4)创建侧重于初级保健环境中艾滋病毒护理的临床有效性的临床结果研究议程。最初的研究重点将是评估当前临床实践指南对感染艾滋病毒的成年人的初级医疗保健的影响，以及这一人群的病毒学、免疫学和临床结果的长期结果。这一前瞻性观察队列的数据将通过使用HIVWatch收集，HIVWatch是卡恩博士开发的一个基于网络的电子医疗记录系统，其中包含在SFGH积极健康实践接受医疗护理的患者的数据。卡恩博士的研究计划得到了他所在部门的热情支持。加州大学旧金山分校艾滋病研究所和其他国家公认的临床研究人员的领导。

James O. Kahn, MD is an Associate Professor of Medicine at the University of California, San Francisco (UCSF), Associate Director of the Positive Health Program (PHP) (formally known as the AIDS Program) at San Francisco General Hospital (SFGH) and Associate Director of the UCSF-Gladstone Institute of Virology and Immunology's Center for AIDS Research (CFAR). Additionally, Dr. Kahn is the former chair of the Committee for Human Research at UCSF. He has completed fellowship training in medical oncology and clinical epidemiology, with an emphasis on research methods. With support from a 3-year Career Development Award from the American Cancer Society, Dr. Kahn attained the experience and skills necessary to become an independent investigator and to build a multidisciplinary research team in patient-oriented research. Dr. Kahn has developed an international reputation as a clinical trialist in patient-oriented HIV/AIDS research, with expertise in the areas of antiretroviral drug development, HIV-1 vaccine development, primary HIV-1 infection and prevention of HIV infection. Dr. Kahn has also been a very active mentor for beginning clinical investigators from diverse backgrounds, including younger physicians on faculty in the PHP, as well as visiting fellows from other countries. All junior faculty supported and mentored by Dr. Kahn are active in patient-oriented research. K-24 support will enable Dr. Kahn to achieve his long-term career goal of establishing a clinical research program that will: (1) integrate a multidisciplinary approach to prevention of HIV-1 infection; (2) conduct exploratory clinical research on the determinants of HIV-1 transmission; (3) include a comprehensive mentoring program for HIV/AIDS clinical investigators; and (4) create a clinical outcomes research agenda that focuses on the clinical effectiveness of HIV care in primary care settings. An initial research focus will be an assessment of the impact of current clinical practice guidelines on the primary medical care of HIV- infected adults, and the long-term virologic, immunologic and clinical outcomes in this population. Data for this prospective, observational cohort will be collected with the use of HIVWatch, a web-based, electronic medical record system developed by Dr. Kahn that contains data on patients who receive their medical care at the Positive Health Practice at SFGH. Dr. Kahn's research program has the enthusiastic support of his deuartment. the leadership of the AIDS Research Institute at UCSF and other nationally recognized clinical researchers.