Observational Cohort of HIV-Infected Persons

HIV 感染者观察队列

• 批准号: 6539323
• 负责人: JAMES S KAHN
• 金额: $ 11.2万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-25 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6539323
• 关键词: AIDS; AIDS /HIV diagnosis; AIDS education /prevention; AIDS therapy; HIV infections; antiviral agents; automated medical record system; clinical chemistry; combination chemotherapy; communicable disease transmission; gender difference; health care professional practice; health care service evaluation; health services research tag; human subject; human therapy evaluation; managed care; medical records; outcomes research; pathologic process; patient care management; patient oriented research; racial /ethnic difference; therapy compliance; virus load

James O. Kahn, MD is an Associate Professor of Medicine at the University of California, San Francisco (UCSF), Associate Director of the Positive Health Program (PHP) (formally known as the AIDS Program) at San Francisco General Hospital (SFGH) and Associate Director of the UCSF-Gladstone Institute of Virology and Immunology's Center for AIDS Research (CFAR). Additionally, Dr. Kahn is the former chair of the Committee for Human Research at UCSF. He has completed fellowship training in medical oncology and clinical epidemiology, with an emphasis on research methods. With support from a 3-year Career Development Award from the American Cancer Society, Dr. Kahn attained the experience and skills necessary to become an independent investigator and to build a multidisciplinary research team in patient-oriented research. Dr. Kahn has developed an international reputation as a clinical trialist in patient-oriented HIV/AIDS research, with expertise in the areas of antiretroviral drug development, HIV-1 vaccine development, primary HIV-1 infection and prevention of HIV infection. Dr. Kahn has also been a very active mentor for beginning clinical investigators from diverse backgrounds, including younger physicians on faculty in the PHP, as well as visiting fellows from other countries. All junior faculty supported and mentored by Dr. Kahn are active in patient-oriented research. K-24 support will enable Dr. Kahn to achieve his long-term career goal of establishing a clinical research program that will: (1) integrate a multidisciplinary approach to prevention of HIV-1 infection; (2) conduct exploratory clinical research on the determinants of HIV-1 transmission; (3) include a comprehensive mentoring program for HIV/AIDS clinical investigators; and (4) create a clinical outcomes research agenda that focuses on the clinical effectiveness of HIV care in primary care settings. An initial research focus will be an assessment of the impact of current clinical practice guidelines on the primary medical care of HIV- infected adults, and the long-term virologic, immunologic and clinical outcomes in this population. Data for this prospective, observational cohort will be collected with the use of HIVWatch, a web-based, electronic medical record system developed by Dr. Kahn that contains data on patients who receive their medical care at the Positive Health Practice at SFGH. Dr. Kahn's research program has the enthusiastic support of his deuartment. the leadership of the AIDS Research Institute at UCSF and other nationally recognized clinical researchers.

James O. Kahn，医学博士，加州大学旧金山分校（UCSF）医学副教授，旧金山总医院（SFGH）积极健康项目（PHP）（正式称为艾滋病项目）副主任，加州大学旧金山分校格莱斯顿病毒学和免疫学研究所艾滋病研究中心（CFAR）副主任。此外，Kahn博士还是UCSF人类研究委员会的前任主席。他完成了医学肿瘤学和临床流行病学的奖学金培训，重点是研究方法。在美国癌症协会3年职业发展奖的支持下，Kahn博士获得了成为独立研究者所需的经验和技能，并在面向患者的研究中建立了一个多学科研究团队。作为面向患者的艾滋病毒/艾滋病研究的临床试验者，Kahn博士在抗逆转录病毒药物开发、艾滋病毒-1疫苗开发、原发性艾滋病毒-1感染和艾滋病毒感染预防领域拥有专业知识，在国际上享有声誉。Kahn博士也是来自不同背景的初级临床研究人员的积极导师，包括PHP教员的年轻医生，以及来自其他国家的访问学者。卡恩博士支持和指导的所有初级教师都积极从事以患者为导向的研究。K-24的支持将使Kahn博士能够实现他建立临床研究项目的长期职业目标，该项目将：(1)整合多学科方法来预防HIV-1感染；(2)开展HIV-1传播决定因素的探索性临床研究；(3)包括对HIV/AIDS临床研究者的全面指导计划；(4)建立临床结果研究议程，重点关注初级保健机构中艾滋病毒护理的临床有效性。最初的研究重点将是评估当前临床实践指南对艾滋病毒感染成人初级医疗保健的影响，以及这一人群的长期病毒学、免疫学和临床结果。这一前瞻性观察队列的数据将使用HIVWatch收集，这是Kahn博士开发的一个基于网络的电子医疗记录系统，其中包含在SFGH积极健康实践中接受医疗护理的患者的数据。卡恩博士的研究项目得到了他所在部门的热情支持。加州大学旧金山分校艾滋病研究所的领导和其他国家认可的临床研究人员。