Mentoring HIV and Translational Scientists and Developing an EMR Based Research

简介（由申请人提供）：James Kahn博士是加州大学旧金山分校的医学教授，专门从事HIV发病机制、疾病建模和健康记录系统应用开发领域的以患者为导向的研究。该提交是他的K24奖（NIH K24MH64384）再竞争五年。卡恩博士在开发研究平台和指导教师方面具有重要影响，重点是以患者为中心的转化研究。他的研究最初集中于原发性HIV感染和暴露后预防，并已发展为疾病建模和医学信息学工具的开发，用于临床护理和临床研究的双重目的。作为K24奖的直接结果，卡恩博士有时间来帮助研究医学信息学，他能够发起一个新的项目，新资助的艾滋病综合临床科学研究网络中心（CNICS），将来自不同电子医疗记录系统的数据结合起来，利用共同的数据元素、定义和策划数据，建立一个新的研究企业。CNICS网络直接导致了“临床研究重新工程奖”（NIH BAA RM-04-23），重点是将电子数据库中的病毒耐药性数据自动添加到研究存储库中。第一个K24奖的支持使Kahn博士能够启动一个试点指导计划，旨在促进下一代从事多学科转化研究的研究人员的成功成长和发展。该指导项目已进入第三个年头，是一个与新资助的临床与转化科学倡议（Clinical and Translational Science Initiative）协同合作的重要而新颖的项目，学员人数已从11人增加到30人。重新竞争的K24将使卡恩博士有足够的时间来发展、成熟和扩展他的指导计划，该计划的重点是对来自个人健康记录和与已建立的电子医疗记录相关的患者门户的数据进行转化研究和分析。K24额外5年的支持将使Kahn博士能够实现建立综合临床研究计划的长期职业目标，具体目标如下：(1)扩展，完善和评估临床和转化研究人员的综合指导计划；(2)通过使用将个人健康记录中的患者衍生信息与电子医疗记录中的临床数据联系起来的患者门户，建立以个人健康记录中的数据元素为重点的新型数据库，从而确定疾病结局的趋势。

DESCRIPTION (provided by applicant): Dr. James Kahn is a Professor of Medicine at UCSF specializing in patient-oriented research in the areas of HIV pathogenesis, disease modeling and the development of health records system applications. This submission is a re-competition of his K24 award (NIH K24MH64384) for an additional five years. Dr. Kahn has had significant impact developing research platforms and mentoring faculty with an emphasis on patient centered translational research. His research initially focused on Primary HIV infection and Post Exposure Prevention and has evolved into disease modeling and the development of medical informatics tools for the dual purpose of clinical care and clinical research. As a direct result of the K24 award, Dr. Kahn had protected time to help study medical informatics and he was able to initiate a novel project, the newly funded Center for AIDS Research Network of Integrated Clinical Science (CNICS) combining data from different electronic medical records systems and leveraging common data elements, definitions and curated data into a novel research enterprise. The CNICS network directly led to a "Re-Engineering of Clinical Research Award" (NIH BAA RM-04-23) focused on automatically adding viral resistance data from electronic databases into a research repository. Support from the first K24 award enabled Dr. Kahn to initiate a pilot mentoring program, designed to facilitate successful growth and development of the next generation of investigators engaged in a multidisciplinary translational research. Entering its third year, the mentoring program is a critically important and novel program synergizing with the newly funded Clinical and Translational Science Initiative and has grown from 11 to 30 mentees. The re-competed K24 will enable Dr. Kahn the committed time for the development, maturation and expansion of his mentoring program for scientists emphasizing translational research and analysis of data derived from personal health records and patient portals linked to estabished electronic medical records. K24 support for an additional 5 year period will enable Dr. Kahn to achieve his long-term career goal of establishing an integrated clinical research program with the following specific aims: (1) Expand, refine and evaluate a comprehensive mentoring program for clinical and translational investigators; (2) Define trends in disease outcomes by establishing novel databases focusing on data elements from personal health records using patient portals that link the patient derived information in personal health records with clinical data in electronic medical records.