REGULATION OF PLASMA FATTY ACID OXIDATION DURING LOW & HIGH INTENSITY EXERCISE

低浓度期间血浆脂肪酸氧化的调节

• 批准号: 6118594
• 负责人: LABROS SIDOSSIS
• 金额: $ 0.32万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-01 至 1999-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6118594
• 关键词: biological products; biomedical resource; cardiovascular system; female; human subject; lipids; male; physical fitness; spectrometry

In the present study we examined the hypothesis that fatty acid oxidation is less during high-intensity exercise than during moderate-intensity exercise because of inhibition of long-chain fatty acid entry into the mitochondria. Six volunteers exercised at 40% peak oxygen consumption for 60 min and at 80% for 30 min on two different occasions. [1-13C]oleate, a long-chain fatty acid, and [1-14C]octanoate, a medium-chain fatty acid, were infused for the duration of the studies. Lipids and heparin were infused during exercise at 80% to prevent the expected decrease in plasma free fatty acid (FFA) concentration. Plasma oleate and total FFA availability were similar in the two experiments. Our data suggest that, in addition to sub-optimal FFA availability, fatty acid oxidation is likely limited during high-intensity exercise because of direct inhibition of long-chain fatty acid entry into mitochondria.

在本研究中，我们检验了脂肪酸 高强度运动时的氧化作用比 中等强度的运动，因为抑制长链脂肪 酸进入线粒体。 6名志愿者的运动量为40% 峰值氧耗60 min和80%氧耗30 min， 不同的场合 [1- 13 C]油酸酯，一种长链脂肪酸，和 [1- 14 C]辛酸，一种中链脂肪酸， 研究的持续时间。 期间输注脂质和肝素 以80%的速度运动，以防止血浆游离脂肪酸的预期下降。 酸（FFA）浓度。 血浆油酸盐和总FFA可用性 在两个实验中相似。 我们的数据表明，在 除了次优FFA可用性，脂肪酸氧化是 可能在高强度运动期间受到限制，因为直接 抑制长链脂肪酸进入线粒体。