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STUDIES OF THE DNA REPLICATION PROCESS

STUDIES OF THE DNA REPLICATION PROCESS
DNA 复制过程的研究
批准号:
6279554
负责人:
MICHAEL E O'DONNELL
金额:
$0.42万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1997
资助国家:
美国
项目状态:
已结题
起止时间:
1997-12-01 至 1998-11-30

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中文摘要
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英文摘要
The 10-subunit replicase of Ecoli has two DNA polymerases for the two strands of duplex DNA. These enzymes are tethered to DNA by a sliding clamp protein that completely encircles DNA. A five-protein "clamp loader" uses ATP to open and close the protein ring around DNA. We are currently trying to characterize the molecular mechanism of the novel clamp loader complex.
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Biochemistry of Eukaryotic Replication Fork and DNA Repair
  • 批准号:
    10550045
  • 项目类别:
  • 资助金额:
    $42.38万
  • 财政年份:
    2023
  • 负责人:
    MICHAEL E O'DONNELL
  • 依托单位:
Biochemical Mechanism and Structure of the Eukaryotic Replication Fork
  • 批准号:
    9906902
  • 项目类别:
  • 资助金额:
    $33.9万
  • 财政年份:
    2015
  • 负责人:
    MICHAEL E O'DONNELL
  • 依托单位:
Biochemical Mechanism and Structure of the Eukaryotic Replication Fork
  • 批准号:
    10396508
  • 项目类别:
  • 资助金额:
    $33.9万
  • 财政年份:
    2015
  • 负责人:
    MICHAEL E O'DONNELL
  • 依托单位:
Biochemical Mechanism of Poxvirus Replication
  • 批准号:
    7074623
  • 项目类别:
  • 资助金额:
    $37.13万
  • 财政年份:
    2005
  • 负责人:
    MICHAEL E O'DONNELL
  • 依托单位:
海外基金