Innovative metabolic mapping to predict and enhance the response of targeted anti-cancer therapies

创新的代谢图谱可预测和增强靶向抗癌疗法的反应

• 批准号: MR/W012030/1
• 负责人: George Poulogiannis
• 金额: $ 192.26万
• 依托单位: Institute of Cancer Research
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FW012030%2F1
• 关键词: Innovative; metabolic; mapping; predict; enhance

Evidence suggests that the way cells consume and process nutrients, collectively known as metabolism, differs between healthy and tumour cells and can even change the way they communicate with adjacent cells, grow, and importantly, respond to therapy. Nutrient availability in the environment where the tumour is growing can also have a fundamental impact on the effectiveness of anti-cancer therapies. This project will draw on the strengths of innovative tools and methods to track the metabolism of breast cancer tumours and pre-clinical models, and identify the metabolic determinants that guide the response to anti-cancer therapies. In this context, it will assist with gaining insight into how certain drugs affect tumour metabolism, and ultimately, how the metabolism of a tumour and its surrounding affect its response to therapy. In the longer term this knowledge will expose weaknesses in the tumour's armour and unveil more effective therapeutic strategies where diet and metabolic targets could help circumvent drug resistance and slow down tumour growth.

有证据表明，细胞消耗和处理营养物质的方式（统称为新陈代谢）在健康细胞和肿瘤细胞之间存在差异，甚至可以改变它们与相邻细胞沟通，生长的方式，重要的是，对治疗的反应。肿瘤生长环境中的营养物质供应也会对抗癌疗法的有效性产生根本性影响。该项目将利用创新工具和方法的优势来跟踪乳腺癌肿瘤和临床前模型的代谢，并确定指导抗癌治疗反应的代谢决定因素。在这种情况下，它将有助于深入了解某些药物如何影响肿瘤代谢，以及最终肿瘤及其周围环境的代谢如何影响其对治疗的反应。从长远来看，这些知识将暴露肿瘤盔甲的弱点，并揭示更有效的治疗策略，其中饮食和代谢目标可以帮助规避耐药性并减缓肿瘤生长。