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L 375,378 EFFECTS ON SERUM CREATININE & GLOMERULAR FILTRATION RATE

L 375,378 EFFECTS ON SERUM CREATININE & GLOMERULAR FILTRATION RATE
L 375,378 对血清肌酐的影响
批准号：
6265136
负责人：
D CRAIG BRATER
金额：
$0.04万
依托单位：
INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6265136
关键词：
anticoagulants blood chemistry clinical research clinical trial phase I creatinine drug screening /evaluation glomerular filtration rate human subject oral administration

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中文摘要
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英文摘要
L-375, 378 is a potent, rapidly binding, reversible, competitive inhibitor of thrombin. It inhibits plasma coagulation triggered by either the intrinsic or extrinsic pathway. In addition L-375, 378 has the advantage of oral activity in animal models versus the traditional parenterally administered thrombin inhibitor agents.
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