EFFECTS OF CHRONIC CONSUMPTION OF MEALS CONTAINING PLANT OR ANIMAL PROTEIN

从植物和动物来源获得蛋白质含量的饮食会吗？ 对NIDDM患者的肾脏和代谢有好处 微量白蛋白尿？这是一项交叉研究，每个研究对象都服务于 作为他/她自己的控制力，按随机顺序进食6周 含有动物(肉类、牛奶)和6周的植物(豆类产品) 蛋白。膳食将在GCRC准备，将是有营养的 除蛋白质来源相同外，还会在家中食用。研究 将在广发中心进行。研究对象为24名男性和女性，年龄在 35岁和75岁NIDDM伴微量白蛋白尿患者的饮食治疗 或饮食加口服抗糖尿病药物(S)。主要结果衡量标准为 A)空腹和餐后肾血流动力学(GFR、RPF)、24小时尿量 尿尿素氮、白蛋白排泄率和肌酐；b) 空腹总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白和甘油三酯，以及餐后 甘油三酯；c)胰岛素、葡萄糖、糖化血红蛋白。和氨基酸图谱。至 确定植物蛋白饮食是否对长期有益 NIDDM高危人群的治疗，数据将分析 饮食对空腹和餐后肾血流动力学、激素的影响 以及氨基酸谱、脂肪代谢和AER的顺序变化。

Will diets which derive their protein content from plant vs animal sources have beneficial renal and metabolic effects in individuals with NIDDM and microalbuminuria? This is a crossover study in which each subject serves as his/her own control by eating, in random order, 6 weeks of meals containing animal (meat, milk) and 6 weeks of plant (soy type products) protein. Meals will be prepared in the GCRC, will be nutritionally equivalent except for protein source, and will be eaten at home. Studies will be conducted in the GCRC. Subjects are 24 males and females between the ages of 35 and 75 with NIDDM and microalbuminuria, treated with diet or diet plus oral anti-diabetic medication(s). Main outcome measures are a) fasting and postprandial renal hemodynamics (GFR, RPF), 24-hr urines for urine urea nitrogen, albumin excretion rate, and creatinine; b) fasting total cholesterol, HDL-c, LDL-c and triglyceride, and postprandial triglycerides; c) insulin, glucose, HbA1c. and amino acid profiles. To establish whether plant protein diets are beneficial in long term treatment of high risk individuals with NIDDM, data will be analyzed for dietary effects upon fasting and postprandial renal hemodynamics, hormonal and amino acid profiles, lipid metabolism, and sequential changes in AER.