EFFECTS OF CHRONIC CONSUMPTION OF MEALS CONTAINING PLANT OR ANIMAL PROTEIN

从植物和动物中获取蛋白质含量的饮食是否会对患有NIDDM和微量白蛋白尿的人的肾脏和代谢产生有益的影响？这是一项交叉研究，每个受试者作为自己的对照，按随机顺序食用6周的含有动物(肉类、牛奶)和6周的植物(豆类产品)蛋白质的膳食。膳食将在GCRC准备，除蛋白质来源外，营养等量，并将在家中食用。我们会在启德资源中心进行研究。受试者为男性和女性，年龄在35岁到75岁之间，患有糖尿病和微量白蛋白尿，采用饮食或饮食加口服降糖药物治疗(S)。主要观察指标是a)空腹和餐后肾血流动力学(GFR、RPF)、24小时尿尿素氮、白蛋白排泄率和肌酐；b)空腹总胆固醇、高密度脂蛋白-c、低密度脂蛋白和甘油三酯以及餐后甘油三酯；c)胰岛素、血糖、糖化血红蛋白。和氨基酸图谱。为了确定植物蛋白饮食是否有益于NIDDM高危个体的长期治疗，将分析饮食对空腹和餐后肾脏血流动力学、激素和氨基酸分布、脂肪代谢以及AER的顺序变化的影响。

Will diets which derive their protein content from plant vs animal sources have beneficial renal and metabolic effects in individuals with NIDDM and microalbuminuria? This is a crossover study in which each subject serves as his/her own control by eating, in random order, 6 weeks of meals containing animal (meat, milk) and 6 weeks of plant (soy type products) protein. Meals will be prepared in the GCRC, will be nutritionally equivalent except for protein source, and will be eaten at home. Studies will be conducted in the GCRC. Subjects are 24 males and females between the ages of 35 and 75 with NIDDM and microalbuminuria, treated with diet or diet plus oral anti-diabetic medication(s). Main outcome measures are a) fasting and postprandial renal hemodynamics (GFR, RPF), 24-hr urines for urine urea nitrogen, albumin excretion rate, and creatinine; b) fasting total cholesterol, HDL-c, LDL-c and triglyceride, and postprandial triglycerides; c) insulin, glucose, HbA1c. and amino acid profiles. To establish whether plant protein diets are beneficial in long term treatment of high risk individuals with NIDDM, data will be analyzed for dietary effects upon fasting and postprandial renal hemodynamics, hormonal and amino acid profiles, lipid metabolism, and sequential changes in AER.