Development of novel therapeutics to prevent or treat preeclampsia

开发预防或治疗先兆子痫的新疗法

• 批准号: nhmrc : 1146128
• 负责人: Dr Natalie Hannan
• 金额: $ 29.14万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/development-novel-therapeutics-treat-preeclampsia/1320595
• 关键词: Development; novel; therapeutics; prevent; treat

Preeclampsia, a major pregnancy complication, affects ~3-8% of pregnancies. There is no cure. We have developed new strategies to tackle the disease, including delivery of agents specifically to the placenta and repurposing drugs safe in pregnancy. We will test whether these strategies can quench disease in models developed in our laboratory, and examine samples from women who participated in clinical trial to treat preeclampsia. This offers new possibilities in the management of preeclampsia.

先兆子痫是一种主要的妊娠并发症，影响约3-8%的妊娠。没有解药。我们已经制定了新的策略来应对这种疾病，包括将药物专门输送到胎盘，并重新使用妊娠期安全的药物。我们将测试这些策略是否可以在我们实验室开发的模型中淬灭疾病，并检查参加临床试验治疗先兆子痫的妇女的样本。这为子痫前期的治疗提供了新的可能性。