Corin, a cardiac enzyme, is critical to pregnancy success

Corin 是一种心肌酶，对于怀孕成功至关重要

• 批准号: nhmrc : GNT1062016
• 负责人: Dr Natalie Hannan
• 金额: $ 31.37万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/corin-cardiac-enzyme-pregnancy-success/1344795
• 关键词: Corin; cardiac; enzyme; critical; pregnancy

Most pregnancy complications, including miscarriage, pre-eclampsia, fetal growth restriction and stillbirth, stem from poor development of the placenta early in pregnancy. Restricted fetal growth in the uterus increases the babies risk of cardiovascular and other disorders in later life. This research will investigate whether Corin, an enzyme discovered in the heart, helps the mothers uterus prepare for pregnancy. Disruptions in Corin production during early pregnancy is likely to be involved in major pregnancy complications and loss.

大多数妊娠并发症，包括流产、先兆子痫、胎儿生长受限和死产，都源于妊娠早期胎盘发育不良。胎儿在子宫内生长受限会增加婴儿日后患心血管疾病和其他疾病的风险。这项研究将调查心脏中发现的一种酶Corin是否有助于母亲的子宫为怀孕做好准备。怀孕早期科林生产的中断可能会导致严重的怀孕并发症和损失。