Nanomedicine targeted delivery of therapeutics to the placenta to treat preeclampsia

纳米医学靶向向胎盘递送治疗剂以治疗先兆子痫

• 批准号: nhmrc : 1127536
• 负责人: Dr Natalie Hannan
• 金额: $ 28.54万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/nanomedicine-targeted-delivery-treat-preeclampsia/948028
• 关键词: Nanomedicine; targeted; delivery; therapeutics; placenta

Preeclampsia, one of the most serious complications of pregnancy, affects around 3-8% of all pregnancies. Sadly, there is no treatment. We have developed a new technique to deliver treatments only to the placenta, sparing the mother and baby from side effects. We will test whether this technique can treat the source of preeclampsia, the placenta, in human and mouse models in our laboratory. This work has potential to offer possibilities of new treatments to other pregnancy complications.

先兆子痫是最严重的妊娠并发症之一，约占所有妊娠的3-8%。可悲的是，没有治疗方法。我们开发了一种新技术，只对胎盘进行治疗，使母亲和婴儿免受副作用。我们将在实验室的人类和小鼠模型中测试这种技术是否可以治疗先兆子痫的来源，胎盘。这项工作有可能为其他妊娠并发症提供新的治疗方法。