The critical role of Corin in placentation

Corin 在胎盘形成中的关键作用

• 批准号: nhmrc : 1062016
• 负责人: Dr Natalie Hannan
• 金额: $ 32.52万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/critical-role-corin-placentation/454953
• 关键词: critical; role; Corin; placentation

Most pregnancy complications, including miscarriage, pre-eclampsia, fetal growth restriction and stillbirth, stem from poor development of the placenta early in pregnancy. Restricted fetal growth in the uterus increases the babies risk of cardiovascular and other disorders in later life. This research will investigate whether Corin, an enzyme discovered in the heart, helps the mothers uterus prepare for pregnancy. Disruptions in Corin production during early pregnancy is likely to be involved in major pregnancy complications and loss.

大多数妊娠并发症，包括流产、先兆子痫、胎儿生长受限和死产，都源于怀孕早期胎盘发育不良。限制胎儿在子宫中的生长会增加婴儿在以后的生活中患心血管疾病和其他疾病的风险。这项研究将调查心脏中发现的一种酶--柯林素是否有助于母亲的子宫为怀孕做准备。早期怀孕期间Corin的生产中断可能与主要的妊娠并发症和丢失有关。