MECHANISM OF INSULIN AND IGF-1 ACTION ON SKELETAL MUSCLE BLOOD FLOW

胰岛素和 IGF-1 对骨骼肌血流的作用机制

• 批准号: 6118190
• 负责人: EUGENE Joseph BARRETT
• 金额: $ 2.81万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6118190
• 关键词: angiogenesis; capillary bed; clinical research; human subject; insulin; insulinlike growth factor; noninsulin dependent diabetes mellitus; obesity; striated muscles

Over the past 4 years considerable data has indicated that insulin increases skeletal muscle blood flow in healthy humans and insulin- resistance in NIDDM and obese skeletal muscle is accompanied by a diminished vascular response. It is not known whether the increase in muscle blood flow is due to enhanced flow to previously perfused muscle or to recruitment of new capillary beds. Using two techniques developed in our laboratories, we will test the hypothesis that insulin and IGF-I act to open new capillary beds. Recent studies with this protocol have now demonstrated an effect of physiologic doses of insulin to increase muscle capillary perfusion volume in normal human skeletal muscle. These are the first studies that have provided measurements of capillary blood volume in human muscle. An abstract describing these results has been submitted to the June meeting of the American Diabetes Association. Current studies are focusing now on comparing the effects of insulin in healthy, lean individuals, healthy obese individuals, and obese individuals with Type II diabetes.

在过去的4年中，大量的数据表明，胰岛素增加健康人的骨骼肌血流量，并且NIDDM和肥胖骨骼肌中的胰岛素抵抗伴随着血管反应减弱。 目前尚不清楚肌肉血流量的增加是由于先前灌注的肌肉的流量增加还是由于新毛细血管床的募集。 使用我们实验室开发的两种技术，我们将测试胰岛素和IGF-I作用于打开新毛细血管床的假设。 最近使用该方案的研究现已证明生理剂量的胰岛素对增加正常人骨骼肌中的肌肉毛细血管灌注量的作用。 这些是第一个提供人体肌肉中毛细血管血容量测量的研究。 描述这些结果的摘要已提交给美国糖尿病协会6月的会议。 目前的研究集中在比较胰岛素在健康、瘦型个体、健康肥胖个体和肥胖II型糖尿病个体中的作用。